Bioequivalence and Bioavailability Forum

When is a BE study futile? [Power / Sample Size]

posted by ElMaestro  – Denmark, 2011-11-01 10:59 (5343 d 14:35 ago) – Posting: # 7570
Views: 9,454

Hi Dr_Dan,

❝ What about an add-on design?

You are reading my thoughts, I think.
A background for my question is that I am fiddling a teenytiny bit with two-stage designs like those of Potvin et al. In the second step the target nominal power is 80% but due to the nature of the approach this figure is in some cases not achieved. Thus if we can define a realistic bsolute lower limit for power then we can tweak the method parameters so as to keep power above the magical or arbitrary threshold.
More info to follow, I hope.

Best regards,
EM.

Complete thread:

• When is a BE study futile? ElMaestro 2011-10-31 09:17 
  • When is a BE study futile? Dr_Dan 2011-10-31 09:46
    • When is a BE study futile?ElMaestro 2011-11-01 09:59
      • Power in the 2-stage design d_labes 2011-11-01 10:28
  • When is a BE study futile? Dr_Dan 2011-10-31 12:55
  • When is a BE study futile? Helmut 2011-10-31 14:41
    • When is a BE study futile? vinayshed 2011-11-01 05:59
  • Minimum target power? d_labes 2011-11-01 10:04
    • ethics and power ElMaestro 2011-11-01 10:46
      • ethics and power d_labes 2011-11-01 11:28
        • ethics and power Ohlbe 2011-11-01 22:57
          • ethics and power ElMaestro 2011-11-02 09:27
            • ethics and power Ohlbe 2011-11-02 11:00
      • ethics and power Dr_Dan 2011-11-01 13:10
        • ethics and power ElMaestro 2011-11-01 13:53
          • When does power become unethical? Dr_Dan 2011-11-02 10:55
            • When does power become unethical? ElMaestro 2011-11-02 12:01