Bioequivalence and Bioavailability Forum • Expected deviation in sample size estimation

Expected deviation in sample size estimation [Power / Sample Size]

posted by Dr_Dan – Germany, 2011-06-10 17:06 (5497 d 14:43 ago) – Posting: # 7106
Views: 7,047

Dear Helmut

❝ If you take the points mentioned on top into account, it might be reasonable to expect a larger ∆ even for measured ±≤5 %. I’m happy with Skar’s 7.5%.

Yes, I agree. But this is just for your own estimation. In the study protocol I would compensate a ∆ larger than ±≤5% by assuming a higher intra-individual CV% since a naive and inexperienced assessor expects an equivalent product (ideally 1:1 and if differences than not more than 5%. Do you remember the discussion about point estimators and confidence intervals?
Kind regards
Dan

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Kind regards and have a nice day
Dr_Dan

Complete thread:

Expected deviation in sample size calculation Karmegams 2011-06-10 07:54
- Expected deviation in sample size calculation Dr_Dan 2011-06-10 08:51
  - Expected deviation in sample size calculation Karmegams 2011-06-10 09:57
- Expected deviation in sample size calculation ElMaestro 2011-06-10 12:19
  - Expected deviation in sample size estimation Helmut 2011-06-10 13:40
    - Expected deviation in sample size estimationDr_Dan 2011-06-10 15:06
    - Expected deviation in sample size estimation Karmegams 2011-06-13 06:05
      - Expected deviation in sample size estimation GSTATS 2011-06-13 07:36