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RegisterSample size/power for PD BE study 3-way crossover [Power / Sample Size]
Hi jdetlor,
yes, this isn't an lm.
Let's say your have an idea of variability within and between (i guess one could start out with gaussian variability but everything is possibly, especially since the FDA does not like parametrics for this analysis), and some guesses for ED50 and f etc. How do you incorporate the relevant variabilities to simulate the data?
❝ I maybe missing something here, but from my understanding, we are not working with a linear ANOVA model in terms of a cross-over analysis, but with the Emax model and estimating the 'f' parameter or the bioavailability ...
yes, this isn't an lm.
Let's say your have an idea of variability within and between (i guess one could start out with gaussian variability but everything is possibly, especially since the FDA does not like parametrics for this analysis), and some guesses for ED50 and f etc. How do you incorporate the relevant variabilities to simulate the data?
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Sample size/power for PD BE study 3-way crossover Coja66 2011-03-28 14:22
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Sample size/power for PD BE study 3-way crossover Helmut 2011-03-29 14:34
- Sample size/power for PD BE study 3-way crossover Coja66 2011-03-29 15:31
- Sample size/power for PD BE study 3-way crossover Dr_Dan 2011-03-30 10:13
- Sample size/power for PD BE study 3-way crossover Coja66 2011-03-30 11:36
- Sample size/power for PD BE study 3-way crossover ElMaestro 2011-03-30 13:48
- Off topic (W.H.) Helmut 2011-03-30 13:59
- Off topic (W.H.) ElMaestro 2011-03-30 14:54
- Off topic (W.H.) Helmut 2011-03-30 15:05
- Off topic (W.H.) ElMaestro 2011-03-30 14:54
- Off topic (W.H.) Helmut 2011-03-30 13:59
- Sample size/power for PD BE study 3-way crossover ElMaestro 2011-03-31 19:55
- Sample size/power for PD BE study 3-way crossover jdetlor 2011-04-01 15:52
- Sample size/power for PD BE study 3-way crossover ElMaestro 2011-04-01 16:19
- Sample size/power for PD BE study 3-way crossover jdetlor 2011-04-01 16:56
- Sample size/power for PD BE study 3-way crossoverElMaestro 2011-04-01 17:14
- Sample size/power for PD BE study 3-way crossover jdetlor 2011-04-01 21:51
- Sample size/power for PD BE study 3-way crossoverElMaestro 2011-04-01 17:14
- Sample size/power for PD BE study 3-way crossover jdetlor 2011-04-01 16:56
- Sample size/power for PD BE study 3-way crossover ElMaestro 2011-04-01 16:19
- Sample size/power for PD BE study 3-way crossover jdetlor 2011-04-01 15:52
- Sample size/power for PD BE study 3-way crossover ElMaestro 2011-03-30 13:48
- Sample size/power for PD BE study 3-way crossover Coja66 2011-03-30 11:36
- Sample size/power for PD BE study 3-way crossover Dr_Dan 2011-03-30 10:13
- Sample size/power for PD BE study 3-way crossover Coja66 2011-03-29 15:31
- Sample size/power for PD BE study 3-way crossover Helmut 2011-03-29 14:34
Ing. Helmut Schütz