Bioequivalence and Bioavailability Forum • A posteriori power

A posteriori power - No.666 [Power / Sample Size]

posted by Marcel – 2011-03-08 15:13 (5592 d 04:19 ago) – Posting: # 6723
Views: 8,441

❝ Crazy. I guess you planned (!) for power of ≥80% and suffered from one of the followings (or any combination thereof)?

❝ 1. CV_intra higher than expected,

❝ 2. higher drop-out rate than anticipated,

❝ 3. T/R deviating more from 1 than expected.

During a pilot study, we obtained intra-subject CV about half of what is now published, so this authority basically is saying that we underpowered the study because the CV we obtained is not possible. Having read your presentation, I can see why pilot info isn't all that great for sample size estimation. Day 210 is tomorrow, so we'll likely get referred to CMD. Will keep you posted.

Thank you both.

Complete thread:

Consumer risk Marcel 2011-03-08 10:56
- Consumer risk ElMaestro 2011-03-08 11:30
  - Consumer risk Marcel 2011-03-08 12:01
    - Consumer risk ElMaestro 2011-03-08 12:13
    - A posteriori power - No.666 Helmut 2011-03-08 12:27
      - A posteriori power - No.666 Marcel 2011-03-08 12:50
        
        A posteriori power - No.666 ElMaestro 2011-03-08 13:06
        A posteriori power - No.666 Helmut 2011-03-08 13:41
        
        A posteriori power - No.666Marcel 2011-03-08 14:13
        
        A posteriori power - No.666 Helmut 2011-03-08 14:27
        
        A posteriori power - No.666 Marcel 2011-03-08 14:49
        
        A posteriori power - No.666 Helmut 2011-03-08 15:03
        
        A posteriori power - No.666 Marcel 2011-03-08 15:28
        
        ... ElMaestro 2011-03-09 23:16