Bioequivalence and Bioavailability Forum

Budgetary stuff [Power / Sample Size]

posted by d_labes  – Berlin, Germany, 2011-02-02 13:13 (5614 d 15:02 ago) – Posting: # 6543
Views: 8,179

Dear Michael,

❝ The current study budget is <2% of that I am not the only

❝ investigator on the study, and my feeling is that it will probably go

❝ ahead with the current budget, it will just be a matter of how far we can

❝ stretch it.

Seems you need not a BOSS button but a accountancy button .

I recommend you a sample size planning using a superiority t-test with Bonferroni corrected alpha. This will give you the highest sample size among alternative methods. Adjust the CV and the clinically relevant difference until you are comfortable with the number of subjects and you assume that your account staff will bite the bullet.
Remember:

"The sample size calculation is an excuse for a sample size and not a reason"

"Clinically relevant difference: Used in the theory of clinical trials as opposed to cynically relevant difference, which is used in practice."

Stephen Senn in "Statistical issues in drug development"

Complete thread:

• Randomisation & Sample Size – Clinical BA Study Mike_270 2011-02-01 11:39 
  • Randomisation & Sample Size – Clinical BA Study ElMaestro 2011-02-01 12:08
    • Randomisation & Sample Size – Clinical BA Study Mike_270 2011-02-01 13:18
      • Randomisation & Sample Size – Clinical BA Study ElMaestro 2011-02-01 14:24
        • Randomisation & Sample Size – Clinical BA Study Mike_270 2011-02-02 00:47
          • Randomisation ElMaestro 2011-02-02 08:48
  • Take all you can get d_labes 2011-02-02 10:36
    • Take all you can get Mike_270 2011-02-02 11:41
      • Budgetary stuffd_labes 2011-02-02 12:13