Bioequivalence and Bioavailability Forum • Randomisation & Sample Size

Randomisation & Sample Size – Clinical BA Study [Power / Sample Size]

posted by Mike_270 – Australia, 2011-02-02 01:47 (5627 d 03:17 ago) – Posting: # 6533
Views: 8,270

Hi ElMaestro,

❝ In the absence of a model

❝ for it I guess you need to either conduct a pilot trial to get an idea

❝ about the effect size in your pivotal trial or press the 'I feel

❝ lucky'-button.

Thankyou for the advice. In terms of randomisation, did you have any comment about using the Williams design 4 treatment sequence design vs. a single treatment sequence (eg. ABCD)? Is it always better to randomise the treatment sequences even with small patient numbers?

Thanks again,

Michael

Complete thread:

Randomisation & Sample Size – Clinical BA Study Mike_270 2011-02-01 11:39
- Randomisation & Sample Size – Clinical BA Study ElMaestro 2011-02-01 12:08
  - Randomisation & Sample Size – Clinical BA Study Mike_270 2011-02-01 13:18
    - Randomisation & Sample Size – Clinical BA Study ElMaestro 2011-02-01 14:24
      - Randomisation & Sample Size – Clinical BA StudyMike_270 2011-02-02 00:47
        
        Randomisation ElMaestro 2011-02-02 08:48
- Take all you can get d_labes 2011-02-02 10:36
  - Take all you can get Mike_270 2011-02-02 11:41
    - Budgetary stuff d_labes 2011-02-02 12:13