Bioequivalence and Bioavailability Forum • Intra subject CV consideration

Intra subject CV consideration [Power / Sample Size]

posted by Ohlbe – France, 2010-04-14 17:32 (5921 d 03:37 ago) – Posting: # 5130
Views: 6,866

Dear Sriraj,

❝ Obviously the CV% would differ, but my question is- can we consider the

❝ intra CV% from Study-1 to evaluate the sample size for Study-2.

How do you plan to do it ? For example if you have an intra-CV of 25 % in the first study and you expect it to be higher in the second, what are you going to do ? You only know it will be more than 25 %, but you still don't know how much more, and therefore how many extra subjects you need.

Rasheed, you're saying it is possible. Can you explain what your suggestion would be ?

Regards
Ohlbe

—
Regards
Ohlbe

Complete thread:

Intra subject CV consideration Sriraj 2010-04-12 09:39
- Intra subject CV consideration rasheed 2010-04-13 06:21
  - Intra subject CV consideration Sriraj 2010-04-13 09:31
    - Intra subject CV consideration rasheed 2010-04-13 11:19
      - No full quote ! Ohlbe 2010-04-13 12:05
        
        No full quote ! rasheed 2010-04-13 12:25
      - Intra subject CV consideration Sriraj 2010-04-14 09:30
        
        Intra subject CV consideration Dr_Dan 2010-04-14 10:24
        
        Intra subject CV consideration Sriraj 2010-04-14 10:40
        
        Intra subject CV consideration rasheed 2010-04-14 12:35
        Intra subject CV considerationOhlbe 2010-04-14 15:32
- Intra subject CV consideration statistician 2010-09-27 14:51