Bioequivalence and Bioavailability Forum • three period and four period study design

three period and four period study design [Power / Sample Size]

posted by rasheed – 2010-04-13 08:34 (5917 d 19:37 ago) – Posting: # 5102
Views: 10,100
(edited on 2010-04-13 11:59)

Dear yuvrajkatkar

First of all I would like to tell u that if number of periods or sequences are greater than the treatments which are to be compared, this refers to a higher order crossover design, such a design u mentioned in ur query, model for the crossover design and higher order crossover design are different so point estimate obtained from both designs are not similar so there is no way to obtaine the CV for the 2 X 2 crossover design based on the information obtained from higher order crossover design, you should consider the point estimate and 90% CI from 2 X 2 crossover design to obtained the CV for 2X2 crossover design,

best regerds

rasheed.

Edit: Full quote removed. Please delete anything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Ohlbe]

Complete thread:

three period and four period study design yuvrajkatkar 2010-04-03 09:01
- three period and four period study designrasheed 2010-04-13 06:34
- There is a way: CV intra from CI of a replicate study d_labes 2010-04-14 09:56
  - There is a way: CV intra from CI of a replicate study rasheed 2010-04-14 13:05
    - Basic knowledge expected Ohlbe 2010-04-14 15:52
      - Logarithms are the key d_labes 2010-04-14 16:45