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RegisterNumber of subjects [Power / Sample Size]
Dear All,
How can I argue for the increased number of subjects in case of a highly variable drug? To set the power to 90% (from 80%) or should I refer to the very high CV% (for example 45%, power=80%)?
Which is less risky? I think the latter one.
I think that the power could not be changed subsequently if the biostudy failed because of 90% power but would pass with 80%.
Please confirm and advise.
When is it needed to increase the power to 90%?
Thanks in advance!
Best regards,
olacy
How can I argue for the increased number of subjects in case of a highly variable drug? To set the power to 90% (from 80%) or should I refer to the very high CV% (for example 45%, power=80%)?
Which is less risky? I think the latter one.
I think that the power could not be changed subsequently if the biostudy failed because of 90% power but would pass with 80%.
Please confirm and advise.
When is it needed to increase the power to 90%?
Thanks in advance!
Best regards,
olacy
Complete thread:
- Number of subjectsolacy 2007-02-02 15:10
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- 80% or 90% power? Helmut 2007-02-07 18:23
- 80% or 90% power? olacy 2007-02-15 10:41
- 80% or 90% power? Helmut 2007-02-07 18:23
Ing. Helmut Schütz