Bioequivalence and Bioavailability Forum • population parameter

population parameter [Power / Sample Size]

posted by martin – Austria, 2009-05-06 00:59 (6260 d 00:31 ago) – Posting: # 3652
Views: 11,837

Dear EM !

what I tried to explain is that your “shocking data” are due to the believe/assumption regarding the true R/T ratio. in the case of R/T=1, power based on the danish requirement increases as sample size increases but still requiring a larger sample size (IMHO) compared to the “usual requirement” for a given power.

A 2nd attempt to answer your question: yes; on the assumption of R/T=0.95 it will be rather difficult to find a sample size for a power of 80% (power does not monotonically increase with sample size) whereas on the assumption of R/T=1 you will find a sample size to show BE with a power of at least 80%.

best regards

martin

Complete thread:

Power with a Danish twist ElMaestro 2009-05-05 19:49
- population parameter martin 2009-05-05 21:32
  - population parameter ElMaestro 2009-05-05 21:48
    - population parametermartin 2009-05-05 22:59
- Wrong Question Answer in Danish d_labes 2009-05-08 09:49
  - Danish numbers d_labes 2009-05-08 15:53
    - Danish numbers ElMaestro 2009-05-08 20:19
- Power with a Danish twist Helmut 2009-05-08 13:23
  - Power with a Danish twist d_labes 2009-05-08 16:06
    - Power with a Danish twist Helmut 2009-05-08 16:15
  - Power with a Danish twist ElMaestro 2009-05-08 19:40
- Power with a Danish twist Helmut 2009-05-08 16:56
  - Power with a Danish twist ElMaestro 2009-05-08 19:17