Bioequivalence and Bioavailability Forum

HI every one,

Paired equivalence method:
sample size-> Paired equivalence->multiplicative
1) multiplicative

Cv=0.62 T/R=0.95 POWER=0.80, LOWER=0.80 UPPER=1.25 then N=72
Cv=62 T/R=0.95 POWER=0.80, LOWER=80 UPPER=125 then N=1774

sample size-> Paired equivalence->Additive
2) Additive

Cv=0.62 T/R=0.95 POWER=0.80, LOWER=0.80 UPPER=1.25 then N=108
Cv=62 T/R=0.95 POWER=0.80, LOWER=80 UPPER=125 then N=108

Two-sample equivalence method:
sample size-> Two-sample equivalence->multiplicative
1) multiplicative

Cv=0.62 T/R=0.95 POWER=0.80 LOWER=0.80 UPPER=1.25 N=141
Cv=62 T/R=0.95 POWER=0.80 LOWER=80 UPPER=125 N=3546

sample size-> Two-sample equivalence->Additive
2) Additive
Cv=0.62 T/R=0.95 POWER=0.80 LOWER=0.80 UPPER=1.25 N=213
Cv=62 T/R=0.95 POWER=0.80 LOWER=0.80 UPPER=1.25 N=213


which method we have to take for finding sample size in BA/BE. Which method is accepted by regulators. give suggestion to me.
thanks in advance.
suri

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Edit: Subject line changed; please try to be more specific the next time. Helmut