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RegisterParallel design with 3 arms adjustment needed ? [Power / Sample Size]
Sorry if this is a basic question.
I have to calculate a sample size for a parallel design with 1 test product and 3 references.
We would like to know if the Test is Bioequivalent to the reference 1, then to the reference 2 and then to the reference 3 (not simulateneously of course !).
Q1. Should I adjust for the multiplicity of tests error (i.e. as a Bonferroni adjustment to the alpha = alpha/number of planned comparisons) ?
Q2. Should I use the sample size calculations as in a 0ne-test one-treatment parallel design (as in Julious's Tutorial pp. 1969-70-71, Stat in Medicine) ?
Q3. Or maybe I should work on a alpha=0.05 with an allocation ratio (r in the equation) of 1/4 ?
Your advices will be more than welcome. Thanks in advance
Sukimmm
I have to calculate a sample size for a parallel design with 1 test product and 3 references.
We would like to know if the Test is Bioequivalent to the reference 1, then to the reference 2 and then to the reference 3 (not simulateneously of course !).
Q1. Should I adjust for the multiplicity of tests error (i.e. as a Bonferroni adjustment to the alpha = alpha/number of planned comparisons) ?
Q2. Should I use the sample size calculations as in a 0ne-test one-treatment parallel design (as in Julious's Tutorial pp. 1969-70-71, Stat in Medicine) ?
Q3. Or maybe I should work on a alpha=0.05 with an allocation ratio (r in the equation) of 1/4 ?
Your advices will be more than welcome. Thanks in advance
Sukimmm
Complete thread:
- Parallel design with 3 arms adjustment needed ?sukimmm 2008-10-20 02:53
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Parallel design with 3 arms adjustment needed ? Helmut 2008-10-20 11:42
- Parallel design with 3 arms adjustment needed ? sukimmm 2008-10-20 19:44
- Multiple references in BE Helmut 2008-10-20 20:10
- Multiple references in BE sukimmm 2008-10-20 21:11
- Multiple references in BE Helmut 2008-10-20 20:10
- Parallel design with 3 arms adjustment needed ? sukimmm 2008-10-20 19:44
- Parallel design with 3 arms adjustment needed ? Helmut 2008-10-20 11:42
Ing. Helmut Schütz