Bioequivalence and Bioavailability Forum • total (pooled) variance: examples

total (pooled) variance: examples [Power / Sample Size]

posted by zizou – Plzeň, Czech Republic, 2023-04-21 23:23 (1140 d 00:20 ago) – Posting: # 23536
Views: 10,785
(edited on 2023-04-22 00:24)

Dear BEQool,
yes for intra-subject CV and
no for inter/total-subject CVs in general.

The equations stated above are valid for 2-treatment crossover designs.

However e.g. for a 3×6×3 crossover design, i.e. with 3 treatments (R1R2T or pilot T1T2R), we may estimate

intra-subject variability as
\(CV_e(\%)=100\sqrt{e^{MS_e}-1}\)
inter-subject variability as
\(CV_s(\%)=100\sqrt{e^{(MS_s{-}MS_e)/\color{Blue} 3}-1}\)
total (pooled) variability as
\(CV_p(\%)=100\sqrt{e^{(MS_s{+}MS_e)/\color{Blue} 3}-1}\)

Best regards,
zizou

Complete thread:

Sample size estimation for parallel design Nav Coelho 2007-07-20 16:14
- Parallel designs (total variance) Helmut 2007-07-20 16:29
  - Parallel designs (total variance) Nav Coelho 2007-07-20 18:38
    - CV-intra # 60% CV-inter Helmut 2007-07-22 01:17
    - total (pooled) variance: examples Helmut 2007-07-23 17:44
      - total (pooled) variance: examples Nav Coelho 2007-07-23 19:58
      - total (pooled) variance: examples BEQool 2023-04-18 09:59
        
        Higher-Order Crossovers Helmut 2023-04-20 10:19
        
        Higher-Order Crossovers BEQool 2023-04-21 07:53
        
        total (pooled) variance: exampleszizou 2023-04-21 21:23
        
        total (pooled) variance: examples BEQool 2023-04-22 18:20
        
        total (pooled) variance: examples zizou 2023-04-22 21:06
        
        total (pooled) variance: examples BEQool 2023-04-25 10:57
        
        total (pooled) variance: examples zizou 2023-04-25 22:43
        
        total (pooled) variance: examples BEQool 2023-05-04 08:17
- Sample size estimation for parallel design Dipesh Jayswal 2007-07-24 08:52