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Register3 treatments with two-at-a-time approach [Power / Sample Size]
Dear all,
First, thank you to the authors of PowerTOST and the maintainers of this wonderful forum.
I have a question about how the sample size is calculated for 1 test (A) and 2 references (B and C) based on 3x6x3 design. I am interested in showing the BE based on both A/C and B/C. If I were to use the two-at-a-time analysis approach, can I use the following function to get the sample size?
Based on this output, I am to assign 20/6 ~ 4 participants in each of the 6 sequences. I am hoping my reasoning is correct
Also, I was unable to find any reference for the sample size calculation and wondered if anyone can kindly point me to the right direction.
Thank you!
Edit: Category changed; see also this post #1. [Helmut]
First, thank you to the authors of PowerTOST and the maintainers of this wonderful forum.
I have a question about how the sample size is calculated for 1 test (A) and 2 references (B and C) based on 3x6x3 design. I am interested in showing the BE based on both A/C and B/C. If I were to use the two-at-a-time analysis approach, can I use the following function to get the sample size?
sampleN.TOST(CV = 0.2, design = "2x2")
Sample size (total)
n power
20 0.834680 Based on this output, I am to assign 20/6 ~ 4 participants in each of the 6 sequences. I am hoping my reasoning is correct
Also, I was unable to find any reference for the sample size calculation and wondered if anyone can kindly point me to the right direction.
Thank you!
Edit: Category changed; see also this post #1. [Helmut]
Complete thread:
- 3 treatments with two-at-a-time approachchrisk 2022-08-01 07:03
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- 3 treatments with two-at-a-time approach Helmut 2022-08-01 13:41
- 3 treatments with two-at-a-time approach chrisk 2022-08-01 17:56
- 3 treatments with two-at-a-time approach Helmut 2022-08-01 13:41
Ing. Helmut Schütz