Bioequivalence and Bioavailability Forum

Dear all (and esp. our expert in probability zizou),

say, we have $\small{n}$ studies, each powered at 90%. What is the probability (i.e., power) that all of them pass BE?

Let’s keep it simple: T/R-ratios and CVs are identical in studies $\small{1\ldots n}$. Hence, $\small{p_{\,1}=\ldots=p_{\,n}}$. If the outcomes of studies are independent, is $\small{p_{\,\text{pass all}}=\prod_{i=1}^{i=n}p_{\,i}}$, e.g., for $\small{p_{\,1}=\ldots=p_{\,6}=0.90\rightarrow 0.90^6\approx0.53}$?
Or does each study stand on its own and we don’t have to care?