Bioequivalence and Bioavailability Forum • 111.11 for NTIDs

111.11 for NTIDs [Power / Sample Size]

posted by Helmut – Vienna, Austria, 2018-02-06 01:12 (3057 d 20:58 ago) – Posting: # 18361
Views: 26,026

Hi Astea,

❝ ❝ I’m not willing to accept 111.11%. Heck, with an acceptable ∆ of 10% we get \(100(1-\Delta)^{-1}=111.1\dot{1}\) – nothing else! I will not forget my second-grade math only cause it’s claimed ex cathedra by the oracle. Had to swallow already rounding of the CI. Double rounding? Gimme a break!

❝ Then why do we use 80,00? "Because in the former case the numbers look nicer and are easier to remember :-D

Yep, I’ve been there.

❝ Of course 111.00 is nonsense and should be forgotten.

Like 111.11. Every idiot should see that \(\sqrt{0.9\times 0.9^{-1}}=\sqrt{0.9/0.9}=1\) which is not the fucking same as
\(\sqrt{0.9\times 1.1111}=0.9999949999874999374996093722656\ldots\)
In R-speak:

identical(sqrt(0.9*0.9^-1), 1)

[1] TRUE

identical(sqrt(0.9*1.1111), 1)

[1] FALSE

Heck, we want the acceptance range in log-scale to be symmetrical around Zero and not –5·10^–6. :angry:

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Sample size for 4-period 4-sequence crossover BE study Bryony Simmons 2018-02-01 12:16
- function sampleN.TOST of package PowerTOST Helmut 2018-02-01 13:01
  - Alpha adjustment in higher order crossover d_labes 2018-02-01 14:01
    - Deficiencies Helmut 2018-02-01 15:48
      - Deficiencies nobody 2018-02-01 17:10
      - Deficiencies d_labes 2018-02-01 18:57
        
        Deficiencies Relaxation 2018-02-02 11:12
        
        Deficiencies nobody 2018-02-02 12:49
        Deficiencies Helmut 2018-02-02 16:14
        
        Deficiencies Relaxation 2018-02-02 19:41
        
        alpha... where is omega? Astea 2018-02-02 21:45
        
        α and no ω Helmut 2018-02-02 23:39
        
        TIE for NTIDs d_labes 2018-02-04 12:40
        
        TIE for NTIDs Astea 2018-02-04 20:04
        
        TIE for NTIDs Helmut 2018-02-05 01:01
        
        TIE for NTIDs d_labes 2018-02-05 16:40
        
        TIE for NTIDs Helmut 2018-02-05 17:49
        
        TIE for NTIDs d_labes 2018-02-05 22:17
        
        TIE for NTIDs Helmut 2018-02-06 12:34
        
        TIE for NTIDs d_labes 2018-02-05 16:35
        
        bow TIE for NTIDs Astea 2018-02-05 17:52
        
        bow TIE for NTIDs Helmut 2018-02-05 18:10
        
        111.11 for NTIDs Astea 2018-02-05 19:27
        
        111.11 for NTIDsHelmut 2018-02-06 00:12
        
        bow TIE for NTIDs d_labes 2018-02-05 22:33