Bioequivalence and Bioavailability Forum • CVintra for Cmax > AUC, therefore use AUC for sample size?

CVintra for Cmax > AUC, therefore use AUC for sample size? [Power / Sample Size]

posted by ElMaestro – Denmark, 2017-08-08 01:04 (3244 d 10:59 ago) – Posting: # 17679
Views: 11,072

Hi nobody,

❝ Any thoughts on this approach?

What a load of absolute nonsense.

And it is of a dangerous kind because it:

Misleads the guys with spreadsheets into cheaper but seemingly better studies.
Increases the likelihood of failure.

= it increases the risk of futile exposure of volunteers.

I am serious, this is deeply problematic cf. e.g. the Helsinki Declaration and the general GCP principles. This is much worse than the recent Midichloria case.
Check the reference list in that publication for a good laugh, by the way.

Edit: Background “Predatory Journals Hit By ‘Star Wars’ Sting” [Helmut]

—
Pass or fail!
ElMaestro

Complete thread:

CVintra for Cmax > AUC, therefore use AUC for sample size? nobody 2017-08-07 17:14
- CVintra for Cmax > AUC, therefore use AUC for sample size? Helmut 2017-08-07 18:40
  - CVintra for Cmax > AUC, therefore use AUC for sample size? nobody 2017-08-07 19:52
    - Crap… Helmut 2017-08-07 20:29
      - Crap… nobody 2017-08-07 21:31
- CVintra for Cmax > AUC, therefore use AUC for sample size?ElMaestro 2017-08-07 23:04
  - CVintra for Cmax > AUC, therefore use AUC for sample size? nobody 2017-08-08 10:06
- CVintra for Cmax > AUC, therefore use AUC for sample size? jag009 2017-08-09 06:21
  - CVintra for Cmax > AUC, therefore use AUC for sample size? nobody 2017-08-09 17:11