Bioequivalence and Bioavailability Forum • Don’t use the formula by Chow, Shao, Wang!

Don’t use the formula by Chow, Shao, Wang! [Power / Sample Size]

posted by DavidManteigas – Portugal, 2017-08-03 18:12 (2824 d 12:06 ago) – Posting: # 17657
Views: 19,993

Thank you for the clarification Helmut, very helpful as always.

In the example you've mentioned on page 260 there is also another mistake, since z0.10 is 1.28 and not 0.84, so according to the reduced formula, 28 subjects per sequence would be necessary and not the reported 21. Still, significantly lower than the sample obtained with sampleNTOST.

Complete thread:

sample size in bioequivalence studies daryazyatina 2017-08-03 09:34
- sample size in bioequivalence studies BE-proff 2017-08-03 09:55
  - sample size in bioequivalence studies daryazyatina 2017-08-03 10:08
- sample size in bioequivalence studies ElMaestro 2017-08-03 10:17
  - sample size in bioequivalence studies daryazyatina 2017-08-03 10:58
    - sample size in bioequivalence studies DavidManteigas 2017-08-03 12:40
      - sample size in bioequivalence studies daryazyatina 2017-08-03 13:46
      - Don’t use the formula by Chow, Shao, Wang! Helmut 2017-08-03 15:37
        
        Don’t use the formula by Chow, Shao, Wang! daryazyatina 2017-08-03 15:52
        Don’t use the formula by Chow, Shao, Wang!DavidManteigas 2017-08-03 16:12
        
        Don’t use the formula by Chow, Shao, Wang! Helmut 2017-08-03 16:33
        
        Don’t use the Book by Chow, Shao, Wang! d_labes 2017-08-16 16:01
    - compromised power Helmut 2017-08-03 16:04
      - compromised power daryazyatina 2017-08-04 08:15
        
        terminology Helmut 2017-08-04 12:41
        
        terminology daryazyatina 2017-08-16 10:12
        
        terminology Helmut 2017-08-16 18:54
- sample size in bioequivalence studies balinskyi 2018-06-03 12:58