Bioequivalence and Bioavailability Forum

Yessir! Common sense! [Power / Sample Size]

posted by Helmut  – Vienna, Austria, 2016-08-24 15:53 (3584 d 12:21 ago) – Posting: # 16569
Views: 15,162

Hi ElMaestro,

❝ For once I actually disagree with Helmut. At least, I think I do if I got his post right.

Only one greek letter in my post. I have written there:

❝ Doing the math is just the first step. Before you pool CV I would suggest to inspect whether the confidence intervals of the CVs overlap […]. If not, try to find out why (different CROs, populations, bioanalytical methods, …). Use common sense to decide which CVs are reliable enough to pool.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Why do we need pooled CV? BE-proff 2016-08-24 08:48 
  • Maximum CV might be misleading Helmut 2016-08-24 12:07
    • Maximum CV might be misleading BE-proff 2016-08-26 10:41
      • Pooling – example Helmut 2016-08-26 11:34
        • Pooling – example BE-proff 2016-12-28 14:37
          • in my protocols… Helmut 2016-12-29 12:27
  • Why do we need pooled CV? ElMaestro 2016-08-24 13:03
    • Yessir! Common sense!Helmut 2016-08-24 13:53
      • Common sense weighting before pooling mittyri 2016-08-24 15:13
    • Gut feeling is the answer! DavidManteigas 2016-08-25 11:09
      • The reasons not to pool Astea 2016-08-26 20:40
        • The reasons not to pool mittyri 2016-08-28 22:05
        • Know your drug/formulation! Helmut 2016-08-29 11:56