Bioequivalence and Bioavailability Forum

Why do we need pooled CV? [Power / Sample Size]

posted by BE-proff – 2016-08-24 10:48 (3168 d 22:39 ago) – Posting: # 16566
Views: 14,309

Hi All,

As my statistics background is rather poor (shame on me) I can't understand purpose of pooled CV in BE-studies.

Unless I am mistaken this parameters should be calculated when there are several studies with different CVs and we need "adequate" CV (correct? ).

But what prevents us from using the highest CV for sample size calculation?
Any ambushes there?

---

Edit: Category changed. [Helmut]

Complete thread:

• Why do we need pooled CV?BE-proff 2016-08-24 08:48 
  • Maximum CV might be misleading Helmut 2016-08-24 12:07
    • Maximum CV might be misleading BE-proff 2016-08-26 10:41
      • Pooling – example Helmut 2016-08-26 11:34
        • Pooling – example BE-proff 2016-12-28 14:37
          • in my protocols… Helmut 2016-12-29 12:27
  • Why do we need pooled CV? ElMaestro 2016-08-24 13:03
    • Yessir! Common sense! Helmut 2016-08-24 13:53
      • Common sense weighting before pooling mittyri 2016-08-24 15:13
    • Gut feeling is the answer! DavidManteigas 2016-08-25 11:09
      • The reasons not to pool Astea 2016-08-26 20:40
        • The reasons not to pool mittyri 2016-08-28 22:05
        • Know your drug/formulation! Helmut 2016-08-29 11:56