Bioequivalence and Bioavailability Forum • Rescue approaching

Rescue approaching – PowerTOST [Power / Sample Size]

posted by d_labes – Berlin, Germany, 2016-02-23 10:08 (3358 d 03:12 ago) – Posting: # 16021
Views: 9,429

Dear lizhao,

package PowerTOST aka "Swiss army knife for lazy guys dealing with BE studies" has a function CI.RatioF() for calculating the Fieller's confidence interval for the designs "2x2" and "parallel" given estimates of the GMR, CV and CVb(between).

The theoretical background can be found in:

Hauschke et al.
"Sample Size Determination for Proving Equivalence Based on the Ratio of Two Means For Normally Distributed Data"
Statist. Med. 18, 93-105 (1999)

Hauschke D., Steinijans V. and Pigeot I.
"Bioequivalence Studies in Drug Development"
Chapter 10., John Wiley & Sons, Chichester (2007)

—
Regards,

Detlew

Complete thread:

how to construct confidence interval for un-transformed metric? lizhao 2016-02-17 19:01
- how to construct confidence interval for un-transformed metric? jag009 2016-02-17 20:43
- how to construct confidence interval for un-transformed metric? mittyri 2016-02-17 22:34
  - Fieller’s confidence interval Helmut 2016-02-18 13:38
    - Fieller’s confidence interval lizhao 2016-02-22 20:20
      - Fieller’s confidence interval yjlee168 2016-02-23 08:23
      - Rescue approaching – PowerTOSTd_labes 2016-02-23 09:08
        
        Rescue approaching – PowerTOST Weidson 2024-11-28 23:15
        
        Why not base 🇷? Helmut 2024-12-03 13:39
        
        Why not base 🇷? Weidson 2025-02-15 20:42