Bioequivalence and Bioavailability Forum

PE at border of the AR: power ≤0.05! [Power / Sample Size]

posted by Helmut  – Vienna, Austria, 2016-01-14 02:29 (3819 d 00:38 ago) – Posting: # 15825
Views: 14,356

Dear Detlew,

❝ Seems your statement "... any sample size ... with power exactly 0.05." is not thoroughly correct .

As usual you are correct.

Seems that I’ve forgotten my own “Don’t panic!” slide. In the dark ages I used to write in my reports “α ≤0.05” and “≥90% CI” and earned questions.

❝ Think about "The TOST procedure can be quite conservative, i.e. the achieved Type I error rate may be lower than the nominal 0.05 significance level"¹

Rightyright. 2×2×2 crossover, CV 30%, n 12–48:



At GMR 0.8 and sample sizes <49 power starts to drop below 0.05. With n=12 it is only 0.0337.

❝ or "TOST is not the most powerful test".

Leaving the question open: Which is the most powerful test?

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Post hoc Power Jay 2016-01-08 06:49 
  • Post hoc Power ElMaestro 2016-01-08 15:07
  • Post hoc Power Helmut 2016-01-09 14:21
    • Post hoc Power Jay 2016-01-11 10:59
      • PE outside the acceptance range Helmut 2016-01-11 14:02
        • PE outside the acceptance range Jay 2016-01-13 08:24
          • Power for PE outside the acceptance range d_labes 2016-01-13 11:59
          • PE at border of the AR: power ≡ 0.05 Helmut 2016-01-13 12:38
            • PE at border of the AR: power ≡ 0.05 ? d_labes 2016-01-13 13:21
              • PE at border of the AR: power ≤0.05!Helmut 2016-01-14 01:29
                • UMP - uniformly more powerful test d_labes 2016-01-15 20:08
                • PE at border of the AR: power ≤0.05! zizou 2016-01-24 22:12
                  • Smoothing artifact Helmut 2016-01-25 14:15