PE at border of the AR: power ≡ 0.05 [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2016-01-13 13:38 (3808 d 07:11 ago) – Posting: # 15822
Views: 14,213

Hi Jay,

❝ You are right, it was partial replicate design.


No, I was wrong. 3×3 Latin Square ∨ 3×6×3 William’s design partial replicate. In the former two three treatments are compared and in the latter two (where R is administered twice). In the future please give all necessary information. We don’t have a crystal ball.

See Detlew’s comments. When we are considering TOST, it’s simple: Power curves for any sample size intersect at the limits of the BE acceptance range with power exactly 0.05. That’s the rule of the game. If the PE is outside the AR, power will be <0.05. No software needed at all. Thus, given your PE: reformulate.

The jury is out when it comes to RSABE. ;-)

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
23,654 posts in 4,992 threads, 1,571 registered users;
150 visitors (0 registered, 150 guests [including 8 identified bots]).
Forum time: 21:50 CEST (Europe/Vienna)

Scientists often have a naïve faith that
if only they could discover enough facts about a problem,
these facts would somehow arrange themselves
in a compelling and true solution.    Theodosius Dobzhansky

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5