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RegisterSample Size for Drugs Interaction studies [Power / Sample Size]
posted by Helmut 
– Vienna, Austria, 2015-11-04 12:17 (3877 d 19:15 ago) – Posting: # 15612
Views: 7,169
Hi Lara,
Absolutely. A similar statistical model as for BE is applicable.*
The design of DDI studies is more demanding than the statistics (steady state, different half lives, …).
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Search the forum to get some impressions.
❝ Hi Helmut,
▲ Not interested in opinions of other members of the forum? 
❝ Question: Is it correct to use BE sample size estimation for Drugs interaction studies?
Absolutely. A similar statistical model as for BE is applicable.*
H0: Drug interaction
H1: Lack of drug interaction
The design of DDI studies is more demanding than the statistics (steady state, different half lives, …).
Search the forum to get some impressions.- Steinijans VW, Hartmann M, Huber R, Radtke HW
Lack of pharmacokinetic interaction as an equivalence problem
Int J Clin Pharm Ther Toxicol 1991;29(8):323–8
PMID 1601534
—
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Helmut Schütz
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The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Sample Size for Drugs Interaction studies Lara 2015-11-03 23:19
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Sample Size for Drugs Interaction studies d_labes 2015-11-04 11:12
- Sample Size for Drugs Interaction studiesHelmut 2015-11-04 11:17
- Sample Size for Drugs Interaction studies Lara 2015-11-04 18:28
Ing. Helmut Schütz