Bioequivalence and Bioavailability Forum

Main page Policy Latest Posts Abbreviations

Sample size with CV more than 100% [Power / Sample Size]

posted by Jay – India, 2015-11-02 11:47 (3879 d 18:06 ago) – Posting: # 15597
Views: 10,606

Dear all,

In pilot study results of a modified release molecule, the CV obtained for AUC5-t is 114% and the T/R is around 88%.

Can one use CV for more than 100% i.e. 114% in above case for the calculation of pivotal sample size.

Regards,
Jay

Complete thread:

Sample size with CV more than 100%Jay 2015-11-02 10:47
- Why not? d_labes 2015-11-02 11:08
  - Why not? Jay 2015-11-02 11:29
    - Sample size for HVD's d_labes 2015-11-02 13:06
      - EMA: MR – ABEL for partial AUCs Helmut 2015-11-02 14:35
        
        EMA: MR – ABEL for partial AUCs d_labes 2015-11-02 14:48

Admin contact
23,654 posts in 4,992 threads, 1,570 registered users;
138 visitors (0 registered, 138 guests [including 13 identified bots]).
Forum time: 06:54 CEST (Europe/Vienna)

Scientists often have a naïve faith that
if only they could discover enough facts about a problem,
these facts would somehow arrange themselves
in a compelling and true solution. Theodosius Dobzhansky

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC

Ing. Helmut Schütz