Bioequivalence and Bioavailability Forum • Sample size with CV more than 100%

Sample size with CV more than 100% [Power / Sample Size]

posted by Jay – India, 2015-11-02 11:47 (3894 d 11:27 ago) – Posting: # 15597
Views: 10,670

Dear all,

In pilot study results of a modified release molecule, the CV obtained for AUC5-t is 114% and the T/R is around 88%.

Can one use CV for more than 100% i.e. 114% in above case for the calculation of pivotal sample size.

Regards,
Jay

Complete thread:

Sample size with CV more than 100%Jay 2015-11-02 10:47
- Why not? d_labes 2015-11-02 11:08
  - Why not? Jay 2015-11-02 11:29
    - Sample size for HVD's d_labes 2015-11-02 13:06
      - EMA: MR – ABEL for partial AUCs Helmut 2015-11-02 14:35
        
        EMA: MR – ABEL for partial AUCs d_labes 2015-11-02 14:48