Bioequivalence and Bioavailability Forum • CVtotal ≠ CVintra + CVinter

CVtotal ≠ CVintra + CVinter [Power / Sample Size]

posted by Helmut – Vienna, Austria, 2015-05-15 16:07 (4062 d 02:09 ago) – Posting: # 14831
Views: 14,260

Hi John John,

❝ But as hydroxychloroquine has a half-life of elimination of about 50 days, studies are made in parallel, so I don’t have that data.

Heck, this is not the topic of this thread. I gave you some examples in the other thread. CV_total was reported with ~30–35%, both for AUC and C_max.

From the ANOVA of a parallel design use \(\small{CV_\textrm{total}(\%)=100\sqrt{\exp(MSE)-1}}\).

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Complete thread:

Extrapolation john john 2015-05-13 13:36
- CVinter (or CVtotal) from CVintra Helmut 2015-05-13 14:33
  - CVinter (or CVtotal) from CVintra nobody 2015-05-13 14:53
    - OT: Drug Res Helmut 2015-05-13 15:11
      - OT: Drug Res nobody 2015-05-13 15:18
        
        completely OT Helmut 2015-05-13 15:29
        
        completely OT nobody 2015-05-13 15:37
  - CVinter (or CVtotal) from CVintra john john 2015-05-14 12:16
    - CVtotal ≠ CVintra + CVinter Helmut 2015-05-15 13:05
      - CVtotal ≠ CVintra + CVinter john john 2015-05-15 13:13
        
        CVtotal ≠ CVintra + CVinter Helmut 2015-05-15 13:14
        
        CVtotal ≠ CVintra + CVinter john john 2015-05-15 13:50
        
        CVtotal ≠ CVintra + CVinterHelmut 2015-05-15 14:07
        
        CVtotal ≠ CVintra + CVinter john john 2015-05-15 15:07
        
        CVtotal ≠ CVintra + CVinter Helmut 2015-05-15 15:10