Bioequivalence and Bioavailability Forum • pooled / total CV

pooled / total CV [Power / Sample Size]

posted by Helmut – Vienna, Austria, 2015-05-06 17:40 (4061 d 01:34 ago) – Posting: # 14764
Views: 14,697

Hi John × 2

❝ I want the CV inter-subject to calculate the sample size for a parallel design

Nope. You definitely want the total (aka pooled) one. The fact that you observe the PK-response only once in a parallel design does not remove the intra-subject variability. Therefore, what you observe consists of both inter- and intra-subject components.

❝ I'm wrong?

Yes. See this post.

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Complete thread:

CV inter-subject john john 2015-05-06 12:16
- Hydroxychloroquine Helmut 2015-05-06 13:18
  - Hydroxychloroquine john john 2015-05-06 13:28
    - pooled / total CVHelmut 2015-05-06 15:40
  - Hydroxychloroquine nobody 2015-05-06 17:50
    - Lousy review process Helmut 2015-05-06 18:21
      - Lousy review process nobody 2015-05-06 18:47
        
        Lousy review process Helmut 2015-05-06 18:50
        
        Lousy review process nobody 2015-05-06 18:57
      - Lousy review process nobody 2015-05-28 15:53
        
        Lousy review process Helmut 2015-05-28 16:00
        
        Lousy review process nobody 2015-05-28 16:10