Bioequivalence and Bioavailability Forum • Failed study: power <80%!

Failed study: power <80%! [Power / Sample Size]

posted by Helmut – Vienna, Austria, 2015-02-20 20:09 (4137 d 22:27 ago) – Posting: # 14479
Views: 17,970

Hi Monica,

❝ Guess that was enough because I haven´t had any other comment.

Fine.

❝ Another question, Is it correct to use a reference with results out of the limits of IC 90%?, I mean not in 80-125% but with power > 80% for do the maths to get a simple size?

I’m not sure whether I understand you correctly: Do you mean a study where at least one of the confidence limits is outside the acceptance range (e.g., 99–127%)? You could never get a power of 80% in such a case. However, the formula still works.

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Helmut Schütz

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Complete thread:

minimum number of subject in bioequivalence study khaoula 2014-09-27 11:14
- minimum number of subject in bioequivalence study ElMaestro 2014-09-27 11:26
  - minimum number of subject in bioequivalence study khaoula 2014-09-27 23:49
    - “Overpowered” studies due to GLs Helmut 2014-09-28 01:13
      - “Overpowered” studies due to GLs khaoula 2014-09-28 22:36
        
        “Overpowered” studies due to GLs Helmut 2014-09-29 03:51
      - Scientific Validation for the Sample Size Formula mreyes 2014-11-07 19:47
        
        Basic maths Helmut 2014-11-07 20:09
        
        Basic maths mreyes 2014-11-07 20:47
        
        Reference for CI ⇒ MSE Helmut 2014-12-14 01:51
        
        Reference for CI ⇒ MSE mreyes 2015-02-19 19:50
        
        Failed study: power <80%!Helmut 2015-02-20 19:09
        
        Failed study: power <80%! mreyes 2015-02-23 17:07
        
        Reported 99.98%, correct 1.4% Helmut 2015-02-23 17:38
        
        Reported 99.98%, correct 1.4% ElMaestro 2015-02-23 17:51
        
        GMR ∉ AR ⇒ power <5% Helmut 2015-02-24 01:33
        
        GMR ∉ AR ⇒ power <5% mreyes 2015-02-24 17:34