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RegisterSample size for PK linearity [Power / Sample Size]
Hi Detlew!
I sent you a message to get your e-mail adress. Do not expect anything fancy, it is only to avoid using pencil and paper.
I've studied Dose proportionality studies and also Incomplete Block designs but yet did not had to conduct any of those, so I may not be the best person to instruct you. But what I know is the basic knowledge that incomplete block designs would be very good to DP studies when one is interested in assessing dose proportionality with more than 4 or 5 doses, since it's very difficult to conduct a crossover study with more than 4 periods, and a parallel group design does not seem like (IMHO) not a good idea at all. The author only explain how to calculate the sample size for those designs, but does not say if it is worth dealing with it. We decided to conduct our first DP study with a 4-way crossover, only testing 4 doses.
Hope I've been of some help.
❝ Meanwhile I have the paper. But of course interested in your EXCEL sheet.
I sent you a message to get your e-mail adress. Do not expect anything fancy, it is only to avoid using pencil and paper.
❝ Do you have any idea what they do in the paper for incomplete block designs? Is it worth to deal with such designs?
I've studied Dose proportionality studies and also Incomplete Block designs but yet did not had to conduct any of those, so I may not be the best person to instruct you. But what I know is the basic knowledge that incomplete block designs would be very good to DP studies when one is interested in assessing dose proportionality with more than 4 or 5 doses, since it's very difficult to conduct a crossover study with more than 4 periods, and a parallel group design does not seem like (IMHO) not a good idea at all. The author only explain how to calculate the sample size for those designs, but does not say if it is worth dealing with it. We decided to conduct our first DP study with a 4-way crossover, only testing 4 doses.
Hope I've been of some help.
Complete thread:
- Sample size for PK linearity Kro 2009-05-19 10:56
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Sample size for PK linearity Helmut 2009-05-19 13:19
- Sample size for PK linearity Kro 2009-05-19 13:56
- Sample size for PK linearity Helmut 2009-05-19 15:09
- Sample size for PK linearity ElMaestro 2009-05-26 17:26
- Weighting scheme Helmut 2009-05-26 19:52
- Sample size for PK linearity mjons 2011-12-08 18:03
- Sample size for PK linearity Lucas 2014-09-11 21:41
- Sample size for PK linearity - power model d_labes 2014-09-12 15:01
- Power dose proportionality - power model - Correction d_labes 2014-10-01 09:09
- Sample size for PK linearity d_labes 2014-09-13 15:05
- Sample size for PK linearity Lucas 2014-10-13 20:36
- Sample size for PK linearity d_labes 2014-10-14 09:26
- Sample size for PK linearityLucas 2014-10-14 15:24
- Sample size for PK linearity d_labes 2014-10-14 09:26
- Sample size for PK linearity Lucas 2014-10-13 20:36
- Sample size for PK linearity - power model d_labes 2014-09-12 15:01
- Sample size for PK linearity ElMaestro 2009-05-26 17:26
- Sample size for PK linearity Helmut 2009-05-19 15:09
- dose proportionality vs. dose linearity martin 2009-05-25 08:46
- dose proportionality vs. dose linearity Helmut 2009-05-25 14:59
- Sample size for PK linearity Kro 2009-05-19 13:56
- Sample size for PK linearity Helmut 2009-05-19 13:19
Ing. Helmut Schütz