Bioequivalence and Bioavailability Forum • A wee little hole in the coconut

A wee little hole in the coconut [Power / Sample Size]

posted by ElMaestro – Denmark, 2014-10-04 20:13 (4284 d 03:02 ago) – Posting: # 13648
Views: 15,284

Aaaaaaah,

finally got a little crack in the coconut.
Google was my friend but it was hard work: Check this out.

Anyone got the Philips paper from 1990?

Edit half an hour later:
Using the world's best package for power calculation known as power.TOST:




cv=sqrt(exp(0.1003) - 1.0)

sampleN.TOST(CV=cv, theta0=1.1, targetpower=.95)



+++++++++++ Equivalence test - TOST +++++++++++

            Sample size estimation

-----------------------------------------------

Study design:  2x2 crossover 

log-transformed data (multiplicative model)



alpha = 0.05, target power = 0.95

BE margins        = 0.8 ... 1.25 

Null (true) ratio = 1.1,  CV = 0.3248115



Sample size (total)

 n     power

136   0.952220

Had a moment of panic as the numbers apparently didn't match, but they do. Example 3 gave 68 subjects per sequence or 136 in total. Me likey. Gosh I am such a jerk.

—
Pass or fail!
ElMaestro

Complete thread:

Proc power ElMaestro 2014-09-30 11:23
- Proc power d_labes 2014-10-01 09:26
- Proc power jag009 2014-10-01 20:55
  - screen shot ElMaestro 2014-10-01 21:02
    - Paired design d_labes 2014-10-02 13:00
      - Paired design ElMaestro 2014-10-02 13:33
        
        Paired design Helmut 2014-10-02 13:43
        
        Paired design nobody 2014-10-02 14:00
        Paired design ElMaestro 2014-10-02 14:25
        
        A wee little hole in the coconutElMaestro 2014-10-04 18:13
        
        A wee little hole in the coconut Helmut 2014-10-04 19:23
        
        Paired design Ben 2014-10-05 10:43
        
        Paired design ElMaestro 2014-10-05 14:01