Bioequivalence and Bioavailability Forum • Paired design

Paired design [Power / Sample Size]

posted by ElMaestro – Denmark, 2014-10-02 15:33 (4281 d 13:30 ago) – Posting: # 13643
Views: 15,245

Thanks a lot d_labes,

❝ this is power/sample size calculations for the so-called "paired design",

❝ i.e. you have f.i. measurements before/after on the same subject and need a ratio/difference of before vs. after.

❝

❝ N pairs is here the number of such paired observations.

❝ It has nothing to do with number of comparisons, whatever you want to compare.

I am not sure how to get my head around it. 'Before' and 'after' is in the sense of a fixed effect exactly the same as 'T' and 'R': A column of sneaky 1's and 0's here and a column of sexy 1's and 0's there;
in either case we'd be working on y=Blah+e
where Blah has two levels (Before and after, or Test and Reference), leaving out other fixed stuff here because it doesn't affect power.

Could you possibly check what a result from Proc Power would then look like for corr=0.0 and e.g. gmr=0.95, CV=0.25, n=18 or something ? Would that coincide with the usual power calculations from the world's finest package for power calculations widely known as PowerTOST?

Many thanks for your help.

—
Pass or fail!
ElMaestro

Complete thread:

Proc power ElMaestro 2014-09-30 11:23
- Proc power d_labes 2014-10-01 09:26
- Proc power jag009 2014-10-01 20:55
  - screen shot ElMaestro 2014-10-01 21:02
    - Paired design d_labes 2014-10-02 13:00
      - Paired designElMaestro 2014-10-02 13:33
        
        Paired design Helmut 2014-10-02 13:43
        
        Paired design nobody 2014-10-02 14:00
        Paired design ElMaestro 2014-10-02 14:25
        
        A wee little hole in the coconut ElMaestro 2014-10-04 18:13
        
        A wee little hole in the coconut Helmut 2014-10-04 19:23
        
        Paired design Ben 2014-10-05 10:43
        
        Paired design ElMaestro 2014-10-05 14:01