Bioequivalence and Bioavailability Forum • CV calculation

CV calculation [Power / Sample Size]

posted by Helmut – Vienna, Austria, 2014-09-18 03:21 (4290 d 01:59 ago) – Posting: # 13531
Views: 9,197

Hi avrahan,

❝ I have found an old study which the ISCV is not stated in the results. Is it possible to calculate this parameter using IC90 and sample size?

If you mean CI90, yes. Any of my presentations dealing with sample size estimation will give you the required formulas. Then you can calculate the CV manually. More convenient is R / package PowerTOST / function CVfromCI().

❝ The study was performed with 24 subjects - 22 finalized

❝ Cmax: 92.08 - 123.44

❝ AUC0-t 93.08 - 113.87

library(PowerTOST)

CVfromCI(lower=0.9208, upper=1.2344, n=22, design="2x2", alpha=(1-0.9)/2)

[1] 0.2875014

CVfromCI(lower=0.9308, upper=1.1387, n=22, design="2x2", alpha=(1-0.9)/2)

[1] 0.1956711

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Complete thread:

CV calculation avrahan 2014-09-17 21:40
- CV calculationHelmut 2014-09-18 01:21
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