Bioequivalence and Bioavailability Forum • sampleN.RSABE()

sampleN.RSABE() [Power / Sample Size]

posted by AngusMcLean – USA, 2014-06-25 22:05 (4375 d 21:11 ago) – Posting: # 13146
Views: 18,548

Helmut: My apologies I am having difficult getting access to the site and posting. It is a battle and I am distracted by it and making many errors. I have now switched to Firefox to see if that will work.

Yes; the paper is the same paper you recommended, but I have it as 2012

J Pharm Pharmaceut Sci (www.cspsCanada.org) 15(1) 73 - 84, 2012

Laszlo Tothfalusi1 and Laszlo Endrenyi2

I am focusing on Table 4 second part (FDA approach) and I see that at 90% power for GMR=1.1 {as recommended by authors} the sample size needed is 38 subjects for a CV of 30%.

I note that your program in R estimates sample size for RSABE. I will see if I can download and see what it provides.

I will switch back to Explorer and see if I can get it to work.

Angus

Complete thread:

Sample size for replicate design partial AUC AngusMcLean 2014-06-25 02:11
- sampleN.RSABE() Helmut 2014-06-25 02:53
  - sampleN.RSABE() AngusMcLean 2014-06-25 13:42
    - sampleN.RSABE() Helmut 2014-06-25 15:02
      - sampleN.RSABE()AngusMcLean 2014-06-25 20:05
        
        sampleN.RSABE() Helmut 2014-06-25 21:29
        
        sampleN.RSABE() AngusMcLean 2014-06-27 17:37
      - power2.TOST() d_labes 2014-06-30 09:47
        
        power2.TOST() Helmut 2014-06-30 12:02
        
        power2.TOST() ElMaestro 2014-06-30 12:31
        
        Elementary, my dear Watson! Helmut 2014-06-30 12:43
        
        Elementary, my dear Watson! ElMaestro 2014-06-30 13:07