Bioequivalence and Bioavailability Forum • ANOVA not for Tmax!

ANOVA not for Tmax! [Power / Sample Size]

posted by Helmut – Vienna, Austria, 2007-10-03 17:02 (6839 d 05:51 ago) – Posting: # 1158
Views: 13,403

Dear stat_be!

❝ ❝ Please find below data for Tmax of a drug XXX and suggest.

❝ ANOVA for Tmax ??? :surprised:

Ohlbe is right; t_max must not be subjected to any statistical method (e.g., GLM, ANOVA, t-test, F-test,…) requiring continuous variables.
You have to apply a nonparametric method (additive model / untransformed data)* instead - which results in a PE ±0.00, 90% CI [-1.00, +0.75] from your data.

Hauschke D, Steinijans VW and E Diletti
A distribution-free procedure for the statistical analysis of bioequivalence studies
Int J Clin Pharm Ther Toxicol 28(2), 72–8 (1990)

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Complete thread:

can inter sub CV% > intra sub CV%? stat_be 2007-09-27 13:15
- CVinter > CVintra! Helmut 2007-09-27 13:34
  - CVinter > CVintra! stat_be 2007-10-03 07:35
    - CVinter > CVintra! Ohlbe 2007-10-03 10:04
      - ANOVA not for Tmax!Helmut 2007-10-03 15:02
    - CVinter > CVintra! Helmut 2007-10-15 16:15
      - CVinter > CVintra! stat_be 2007-10-16 12:19
        
        CVinter > CVintra! Helmut 2007-10-16 13:15
      - CVinter > CVintra! krishna 2012-11-30 05:46
        
        WinNonlin random vs. fixed model Helmut 2012-11-30 13:54