Bioequivalence and Bioavailability Forum

Dear HS,

Thanks for your reply.

I have some more doubts.
I want the intra CV value of some drugs for sample size calculation.
In case if no pilot study is conducted what can i do?
(I think in most of the BE studies CV is calculated fom literature).
I am a fresher in this field. How can I get the intra CV value from the literature? Is there any web site giving information about drugs CV and all?
From one of your post I understood that we can easily calculate the CV from the MSE of the ANOVA table. But this is possible if we conduct the pilot study (right?).

From the paper "On Sample Size Calculation in Bioequivalence Trials" by Chow and Wang, they give two type formulas for calculation of S.S., one formula for raw data and one for log transformed data. what is the difference between the value of "sigma" in both case?

Usually we use intra CV for the calculation of sample size. Is there any formula for calculating sample size using inter subject CV?

please give some reference for sample size calculation in BE studies

thanks

Mathews