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RegisterCVintra from Mean/SD [Power / Sample Size]
I want help to clear some doubts in sample size calculation for a 2 x 2 crossover design.
I know only the Cmax value of the drug from the literature. It is around 42.34 ± 13.27.
How i can calculate the intra subject CV from this Cmax value? (is it required for Sample Size calculation?)
which value of "delta" we commonly used for calculating Sample Size?
there are different sample size formulas for additive model and multiplicative model? which model we commonly used? why?
Mathews
I know only the Cmax value of the drug from the literature. It is around 42.34 ± 13.27.
How i can calculate the intra subject CV from this Cmax value? (is it required for Sample Size calculation?)
which value of "delta" we commonly used for calculating Sample Size?
there are different sample size formulas for additive model and multiplicative model? which model we commonly used? why?
Mathews
Complete thread:
- CVintra from Mean/SDmathews 2007-09-17 13:04
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- CVintra # Mean/SD Helmut 2007-09-17 15:59
- CVintra # Mean/SD mathews 2007-09-18 11:17
- CVintra # Mean/SD Helmut 2007-09-18 13:51
- Lansoprazole: CVintra? mathews 2007-09-24 11:11
- Lansoprazole: CVintra... Helmut 2007-09-25 01:12
- Lansoprazole: CVintra... mathews 2007-09-25 08:22
- Lansoprazole: CVintra... Helmut 2007-09-25 01:12
- Lansoprazole: CVintra? mathews 2007-09-24 11:11
- CVintra # Mean/SD Helmut 2007-09-18 13:51
- CVintra # Mean/SD mathews 2007-09-18 11:17
- CVintra # Mean/SD Helmut 2007-09-17 15:59
Ing. Helmut Schütz