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RegisterXover or parallel? [Power / Sample Size]
Hi Helmut,
This gave me the idea that it was a PK evaluation study.
"The 10 subjects who received the 30-mg dose in the single-dose phase continued on to the multiple-dose phase and received 30 mg of duloxetine twice daily for 7 days."
I guess they randomized the subject to determine who would receive the 30/60/90 mg dose?
John
❝ Maybe I’m misinterpreting the abstract (I don’t have the article):
“Subjects were randomized to receive a single dose of 30, 60, or 90 mg of duloxetine.”
Smelled of cross-over to me. But your interpretation (parallel) is valid as well.❝ @BK: which design?
This gave me the idea that it was a PK evaluation study.
"The 10 subjects who received the 30-mg dose in the single-dose phase continued on to the multiple-dose phase and received 30 mg of duloxetine twice daily for 7 days."
I guess they randomized the subject to determine who would receive the 30/60/90 mg dose?
John
Complete thread:
- How many sample size about Duloxetine in bioequivalence? bjkim97 2013-06-03 11:13
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- CVtotal ≠ CVinter Helmut 2013-06-03 11:42
- CVtotal ≠ CVinter jag009 2013-06-03 17:01
- Xover or parallel? Helmut 2013-06-03 17:19
- Xover or parallel?jag009 2013-06-03 17:51
- Xover or parallel? Helmut 2013-06-03 18:17
- Xover or parallel?jag009 2013-06-03 17:51
- Xover or parallel? Helmut 2013-06-03 17:19
- CVtotal ≠ CVinter jag009 2013-06-03 17:01
- How many sample size about Duloxetine in bioequivalence? cakhatri 2013-06-05 18:03
- How many sample size about Duloxetine in bioequivalence? bjkim97 2013-06-24 02:52
- CVtotal ≠ CVinter Helmut 2013-06-03 11:42
Ing. Helmut Schütz