Bioequivalence and Bioavailability Forum • CVtotal ≠ CVinter

CVtotal ≠ CVinter [Power / Sample Size]

posted by jag009 – NJ, 2013-06-03 19:01 (4766 d 16:08 ago) – Posting: # 10714
Views: 9,078

Are you guys referring to the following article?

Clin Ther. 2009 May;31(5):1022-36. doi: 10.1016/j.clinthera.2009.05.005.

Pharmacokinetics of duloxetine hydrochloride enteric-coated tablets in healthy Chinese volunteers: a randomized, open-label, single- and multiple-dose study.

Zhao RK, Cheng G, Tang J, Song J, Peng WX.

If so, I don't see how you can extract the intrasubject CV since it was a one treatment (product) PK study carried out to elucidate the SD and MD PK of the drug.

I agree with Helmut.

Thanks
John

Complete thread:

How many sample size about Duloxetine in bioequivalence? bjkim97 2013-06-03 11:13
- CVtotal ≠ CVinter Helmut 2013-06-03 11:42
  - CVtotal ≠ CVinterjag009 2013-06-03 17:01
    - Xover or parallel? Helmut 2013-06-03 17:19
      - Xover or parallel? jag009 2013-06-03 17:51
        
        Xover or parallel? Helmut 2013-06-03 18:17
- How many sample size about Duloxetine in bioequivalence? cakhatri 2013-06-05 18:03
  - How many sample size about Duloxetine in bioequivalence? bjkim97 2013-06-24 02:52