Bioequivalence and Bioavailability Forum

Dear Detlew,

❝ The design constant for Baalam's design is 8 compared to 2 for the simple 2x2x2 crossover (in terms of N(total)). Thus the sample size for Baalam's design is approximately 4 times that of the 2x2x2 crossover, disregarding the different df for both designs.

I know.

❝ Why? Because it is written¹⁾ .

❝ To cite our Jewish Israeli guide with Viennese appeal: "Warum?! Schaun Sie: Steht geschrieben!"

Wonderful! Browsing St. Julious’s writings always gives me headaches.

❝ […] using all data in Chow/Liu²⁾ Chapter 9.2.1 […]

❝ Voilà! Here we have the design const. = 8.

❝ But it's based on carry-over. And PowerTOST claims to deal with models without!

❝ IMHO the same estimate and its variance applies if we omit the carry-over terms in the table above. But I'm not quite sure. The d1 and d2 are then used only for estimating the period effect and adjusting for it in d3,d4.

❝ What puzzles me with this approach is the assumption of a common error variance. And this in a design which allows the assessment of intra-subject variances for T and R.

Sounds familiar. Same in EMA’s crippled ABEL methods A/B…

❝ But I must confess that I didn't really understood St. Julious.

Me too. See above. THX for the elaborate answer! Take my pills now.