Bioequivalence and Bioavailability Forum

two-stage design power 90% second stage Yvonne 2012-08-02 09:50
- two-stage design power 90% second stage ElMaestro 2012-08-02 10:17
  - two-stage design power 90% second stage Yvonne 2012-08-02 11:47
    - two-stage design power 90% second stage ElMaestro 2012-08-02 11:54
- two-stage design power 90% in sample size adaption d_labes 2012-08-02 10:33
  - two-stage design power 90% in sample size adaption ElMaestro 2012-08-02 11:29
    - two-stage design power 90% in sample size adaption Yvonne 2012-08-02 12:06
      - two-stage design power 90% in sample size adaption ElMaestro 2012-08-02 16:59
- Are simulations sufficient? …lenghty post! Helmut 2012-08-02 17:39
  - adjusted alpha = 0.045 d_labes 2012-08-03 11:33
    - adjusted alpha = 0.038 Helmut 2012-08-03 14:26
      - adjusted alpha by sims? d_labes 2012-08-03 15:48
        
        Yeah but, no but, yeah but, no but… Helmut 2012-08-03 16:39
        
        Yeah but, no but ... d_labes 2012-08-07 14:42
        
        Yeah but, no but ... Helmut 2012-08-07 15:14

Sequential designs, draft FDA guidance Loteprednol ElMaestro 2012-07-03 18:33
- What the heck? Helmut 2012-07-03 19:25
  - some unofficial opinion with this regard in Europe Shuanghe 2012-07-04 09:07
    - Great! Helmut 2012-07-04 15:43
      - Great! Shuanghe 2012-07-05 13:48
        
        Potvin & Montague not acceptable at all?! Helmut 2012-07-05 14:57
        
        Powerless Potvin & Montague? d_labes 2012-07-05 16:11
        
        Example w.o. intermediate power Helmut 2012-07-06 02:06
        
        Example w.o. intermediate power d_labes 2012-07-06 08:13
        
        Sims w.o. intermediate power Helmut 2012-07-26 16:20
        
        Potvin & Montague not acceptable at all?! ElMaestro 2012-07-05 16:20
        
        Sims? Helmut 2012-07-05 16:36

Adaptive BE: concepts martin 2012-07-11 20:31
- Adaptive BE: concepts d_labes 2012-07-12 11:53
  - Adaptive BE: concepts martin 2012-07-12 13:36

2-Stage design balakotu 2012-06-21 08:28
- Sequential design, maximum sample size in stage 2 Helmut 2012-06-21 16:05
  - Sequential design, maximum sample size in stage 2 ElMaestro 2012-06-22 01:43
  - Well roared, lion d_labes 2012-06-22 08:45

Two-stage design approach balakotu 2012-06-20 07:18
- Two-stage design approach ElMaestro 2012-06-20 07:34

Potvin C or B? Helmut 2012-06-02 18:54
- Belive in Potvin C? d_labes 2012-06-04 10:34
- Potvin C or B? ElMaestro 2012-06-05 11:45
  - Potvin C or B? Helmut 2012-06-07 15:45
    - Potvin C or B? ElMaestro 2012-06-07 17:01
      - Potvin C or B? Helmut 2012-06-07 18:28

2-stage design - power evaluation d_labes 2011-10-12 11:10
- No opinions out there? d_labes 2011-10-26 09:14
  - Opinion yes, answer no ElMaestro 2011-10-26 11:15
    - Decision scheme without (?) power check d_labes 2011-10-26 13:00
      - Decision scheme without (?) power check ElMaestro 2011-10-26 13:20
        
        Decision scheme 'without' power check d_labes 2011-10-26 14:51
        
        Decision scheme 'without' power check ElMaestro 2011-10-26 15:24
        
        Numerical example d_labes 2011-10-26 16:28
        
        Numerical example ElMaestro 2011-10-26 16:49
        
        Potvin C with unsymmetrical alphas d_labes 2011-10-27 14:54
        
        Potvin B, C, or D? Helmut 2011-10-27 22:52
        Two-stage (classical Pocock) and the FDA Helmut 2011-10-31 02:36
- Weirdo paper ElMaestro 2011-11-30 18:04
  - Weirdo paper Helmut 2011-11-30 23:45
    - Weirdo paper ElMaestro 2011-12-01 07:16

Equations for residual sigmas ElMaestro 2011-11-18 08:11
- When it comes to QR factorisation d_labes 2011-11-18 15:44
  - Potentially solved it ElMaestro 2011-11-20 18:54

Two-Stage Sequential Designs Helmut 2010-05-20 16:53
- Two-Stage Sequential Designs yjlee168 2010-05-20 21:28
  - Two-Stage Sequential Designs Helmut 2010-05-21 01:06
    - EMA: Two-Stage Sequential Designs d_labes 2010-06-15 16:02
      - EMA: Two-Stage Sequential Designs Helmut 2010-06-15 16:23
        
        EMA: Two-Stage Sequential Designs The Outlaw Torn 2011-10-20 10:30
        
        EMA: Two-Stage Sequential Designs Helmut 2011-10-21 15:01
        
        PAR? ElMaestro 2011-10-21 15:23
        
        PAR not yet Helmut 2011-10-21 16:02
        
        PAR not yet The Outlaw Torn 2011-10-25 08:57
        
        PAR not yet The Outlaw Torn 2011-10-27 11:07
        
        Potvin C not acceptable! d_labes 2011-10-27 13:16
        PAR not yet ElMaestro 2011-10-27 13:25
        
        PAR not yet The Outlaw Torn 2011-10-31 07:45
        
        No (?) comment :-( Helmut 2011-10-31 15:04

Two-stage parallel ElMaestro 2011-10-18 04:23
- Two-stage parallel d_labes 2011-10-18 11:03
  - Two-stage parallel ElMaestro 2011-10-18 15:02
    - Interaction needed? d_labes 2011-10-18 16:32

two stage design beman 2011-08-22 15:34
- two stage design ElMaestro 2011-08-22 16:58
- two stage design Helmut 2011-08-22 17:35
  - two stage design beman 2011-08-23 12:37
    - Stage 1 BE d_labes 2011-08-23 14:51
- two stage design extreme d_labes 2011-08-23 13:46

EMA: Two-Stage design joyjac 2011-07-05 07:53
- EMA: Two-Stage design Helmut 2011-07-05 19:38

Potvin method B subtleties d_labes 2011-01-31 14:24
- Potvin method B subtleties jdetlor 2011-02-01 17:17
  - Potvin method B subtleties d_labes 2011-02-02 09:15
    - Potvin method B subtleties jdetlor 2011-02-02 16:08
      - Gould d_labes 2011-02-02 16:25
        
        Gould jdetlor 2011-02-02 17:02
- Another one ... d_labes 2011-02-07 14:32
  - Oops! Helmut 2011-02-07 15:24
    - Oops! d_labes 2011-02-07 16:29
      - Oops! Helmut 2011-02-07 16:47
        
        Oops! ElMaestro 2011-02-07 17:06
        
        Oops! Helmut 2011-02-07 17:17
        
        Oops! ElMaestro 2011-02-07 18:35
        
        Simul'ants in my pants d_labes 2011-02-08 09:07
        
        Need for speed... ElMaestro 2011-02-13 10:57
        
        Need for speed... d_labes 2011-02-15 14:06
        
        Need for speed... ElMaestro 2011-02-15 17:39
        
        Pocock alpha's d_labes 2011-02-16 09:18
        
        ElMaestro's brain ElMaestro 2011-02-16 09:32
        
        ElMaestro's brain d_labes 2011-02-16 10:05
        
        ElMaestro's brain ElMaestro 2011-02-16 12:07
        
        Numbers d_labes 2011-02-16 13:45
- Bonus counter-question ElMaestro 2011-02-07 23:44
  - Speed is the question d_labes 2011-02-08 08:36
- New paper (method D for PE 0.90) Helmut 2011-04-18 12:58
  - New paper (method D for PE 0.90) d_labes 2011-04-19 08:58
    - New paper (method D for PE 0.90) Helmut 2011-04-19 14:30
    - New paper (method D for PE 0.90) ElMaestro 2011-04-19 14:49
      - Stopping criterion # futility rule Helmut 2011-04-19 15:28

Two stage replicated design Priyanka_S 2010-06-24 11:13
- Two stage replicated design Helmut 2010-06-24 12:45
  - Replicate cross-over study done as 2-stage sequential d_labes 2010-06-24 14:51

Two-stage approach (Potvin et al.): model for Stage 2 vezz 2010-06-19 18:35
- Two-stage approach (Potvin et al.): model for Stage 2 Helmut 2010-06-20 21:54