Bioequivalence and Bioavailability Forum

Different power of AUC vs. Cmax at stage I - continuation rules Nisha 2015-09-17 13:28
- Different power of AUC vs. Cmax at stage I - continuation rules ElMaestro 2015-09-17 13:56
  - Different power of AUC vs. Cmax at stage I - continuation rules Nisha 2015-09-17 20:27
    - AUC vs. Cmax ElMaestro 2015-09-17 21:53
    - Assumption Helmut 2015-09-18 00:15

Does unequal alpha distribution make sense? Dr_Dan 2015-05-19 08:29
- Maybe; but watch the TIE! Helmut 2015-05-28 15:04
  - Advantages d_labes 2015-06-05 09:35
    - Advantages ElMaestro 2015-06-05 10:07
      - Advantages – performance measure d_labes 2015-06-05 11:21
        
        Advantages – performance measure Helmut 2015-06-05 13:29
        
        Advantages – performance measure d_labes 2015-06-05 21:27
        
        Advantages – performance measure Helmut 2015-06-05 23:29
        
        Histogram wonder d_labes 2015-06-06 12:58
        
        Histogram charlatanry Helmut 2015-06-09 13:43
        
        Histogram beauty d_labes 2015-06-09 14:55
        
        Histogram beast Helmut 2015-06-09 15:24
- Does unequal alpha distribution make sense? Dr_Dan 2015-05-29 08:33
  - Does unequal alpha distribution make sense? ElMaestro 2015-05-29 09:31
    - Does unequal alpha distribution make sense? nobody 2015-05-29 12:56
      - Old beliefs die hard Helmut 2015-05-29 13:27
        
        Old beliefs die hard nobody 2015-05-29 13:41
        
        Old beliefs die hard Helmut 2015-05-29 18:08
        
        Old beliefs die hard ElMaestro 2015-05-29 18:57
        
        Old beliefs die hard nobody 2015-05-29 20:06
        ♩ ♪♫♬ $·.¸¸.·´$ ·.¸¸. Helmut 2015-06-02 01:52
        
        TSD only an option in exceptional cases Dr_Dan 2015-06-02 08:00
        
        TSD only an option in exceptional cases nobody 2015-06-02 09:23
        
        OT Helmut 2015-06-02 12:07
        
        OT nobody 2015-06-02 12:41
- Banana splits Helmut 2015-06-02 00:48

TSD subjects participation in both stages Dr_Dan 2015-05-12 16:35
- Interesting idea! Helmut 2015-05-12 17:05
  - Interesting idea! Dr_Dan 2015-05-12 18:11
- TSD subjects participation in both stages ElMaestro 2015-05-12 17:22
- TSD subjects participation in both stages - ANOVA d_labes 2015-05-13 09:33

TSDs for RSABE/ABEL Helmut 2015-05-06 02:17
- TSDs for RSABE/ABEL nobody 2015-05-06 11:13
  - TSDs for RSABE/ABEL Helmut 2015-05-06 11:55
    - TSDs for RSABE/ABEL nobody 2015-05-06 12:26
- TSDs for RSABE/ABEL ElMaestro 2015-05-06 12:31
  - TSDs for RSABE/ABEL Helmut 2015-05-06 13:49
- TSDs for RSABE/ABEL - run-time d_labes 2015-05-08 20:47
  - Really worth the efforts? Helmut 2015-05-10 01:11

Advanced example (futility for GMR) Helmut 2015-02-27 02:03
- Advanced example (futility for GMR) d_labes 2015-02-27 09:55
  - Advanced example (futility for GMR) Helmut 2015-02-27 10:43
    - Numbers d_labes 2015-02-27 11:03
      - Typos Helmut 2015-02-27 11:22

Gimmick & survey Helmut 2015-02-20 01:47
- Gimmick & survey nobody 2015-02-20 08:25
  - Gimmick & survey Helmut 2015-02-20 13:01
    - Gimmick & survey nobody 2015-02-20 14:18
      - Speeed! Helmut 2015-02-20 15:38
        
        Speeed! nobody 2015-02-20 16:37
        
        Speeed! Helmut 2015-02-20 16:58
        
        Speeed! nobody 2015-02-20 17:01
        
        Speeed! ElMaestro 2015-02-20 23:48
        
        Speeed! Helmut 2015-02-21 01:11
        
        Unrolled example ElMaestro 2015-02-21 01:32
        
        Unrolled example Helmut 2015-02-21 01:50
        
        Unrolled example ElMaestro 2015-02-21 02:27
        
        Increasing vector & another example Helmut 2015-02-21 13:13
        
        Speeed! nobody 2015-02-21 21:02

Type 1: n2=2 (EMA), no interim power (NL?) Helmut 2015-02-13 13:29
- Type 1: no interim power (NL?) d_labes 2015-02-13 14:53
  - Type 1: no interim power (NL?) Helmut 2015-02-13 15:22

Full Replicate Study Design prashantmohite 2015-01-28 06:56
- Full Replicate Study Design – search the Forum Dr_Dan 2015-01-28 08:38

Two-Stage Design with Fully replicate for CANADA? Rakesh_20 2015-01-22 10:26
- Two-Stage Design with Fully replicate for Canada ElMaestro 2015-01-22 10:56
- RSABE/TSD-combo Helmut 2015-01-22 12:37
  - Fully replicated-conventional ABE/TSD-combo Rakesh_20 2015-01-23 06:32
    - Simulations mandatory Helmut 2015-01-23 12:41

Interim Analysis and Power Emrah Soner Özdeş 2014-12-24 07:38
- Interim Analysis and Power Helmut 2014-12-24 16:22
  - Interim Analysis and Power Emrah Soner Özdeş 2014-12-25 08:36
- Interim Analysis and Power ElMaestro 2014-12-25 12:32
  - Interim Analysis and Power Emrah Soner Özdeş 2014-12-26 08:55
    - R-code & some thoughts Helmut 2014-12-26 17:51
      - R-code & some thoughts Emrah Soner Özdeş 2014-12-29 07:49

Two-stage three-treatment BE study? Oiinkie 2013-07-22 16:03
- Bingo! Helmut 2013-07-22 16:33
  - Bingo! Oiinkie 2013-07-29 10:41
    - Bingo! Helmut 2013-07-29 11:32
      - Bingo! ElMaestro 2013-07-29 12:06
      - Terms in Anova ElMaestro 2013-07-29 16:50
        
        annoying imbalance ElMaestro 2013-07-29 22:37
  - Bingo! jatkins_5 2014-10-30 03:53
    - Yes, however... ElMaestro 2014-10-30 08:59
      - Yes, however... jatkins_5 2014-10-31 23:20

How to find a suitable adjusted α? Helmut 2014-05-31 18:20
- Suitable code for suitable adjusted α d_labes 2014-06-02 08:28
  - Handling inflation Helmut 2014-06-02 14:44
  - Potvin revis(it)ed Helmut 2014-06-02 22:07
    - Potvin revis(it)ed d_labes 2014-06-03 08:47
      - Montague revis(it)ed Helmut 2014-06-03 13:49
      - Pocock’s “natural constant” Helmut 2014-10-13 14:53
        
        Pocock’s “natural constant” ElMaestro 2014-10-13 15:30
        Another “natural constant”? d_labes 2014-10-14 08:56
        
        Λ Helmut 2014-10-14 13:36

SAS code for 2-stage design MGR 2014-05-22 07:45
- SAS code for 2-stage design d_labes 2014-05-22 08:17
- Phoenix/WinNonlin code Helmut 2014-05-22 12:24
  - maybe R too? yjlee168 2014-05-23 21:17
    - RSABE/ABEL in a TSD: Science fiction Helmut 2014-05-23 22:39
  - WinNonlin 5.2.1 setup MGR 2014-07-02 07:08
    - outdated software; mixed vs. fixed effects Helmut 2014-07-02 10:40
      - outdated software; mixed vs. fixed effects MGR 2014-07-03 06:32

Replicate Design Naveen Kumar 2014-06-23 13:19
- Replicate Design ElMaestro 2014-06-23 13:32
  - Science fiction Helmut 2014-06-23 14:53
    - Science fiction Naveen Kumar 2014-06-28 07:26
      - Interim analysis? Helmut 2014-06-28 12:09

Add-on and Two-Stage Designs Mahesh M 2014-06-17 11:12
- Add-on designs obsolete! Helmut 2014-06-17 13:36
  - Add-on designs obsolete! Mahesh M 2014-06-18 06:38
  - Add-on designs obsolete! jag009 2014-06-18 16:04
    - Add-on designs obsolete! Helmut 2014-06-18 19:41