d_labes
★★★

Berlin, Germany,
2010-04-08 17:52
(5103 d 15:02 ago)

Posting: # 5046
Views: 7,419
 

 R use in BE/BA [Surveys]

Dear All!

Since I'm very interested in using R in planning and evaluation of BE/BA studies, but as you know I'm an Old scummy SAS dog :-D somehow lazy to make the transition, here some questions for my and hopefully also your interest:
  1. Do you use R for some aspects in BE/BA statistics (Yes/No)
    if Yes:
    1. Sample size estimation?
    2. Non-compartmental PK evaluation?
    3. Concentration time graphics?
    4. Statistical evaluation (BE decision)?
    5. Clinical data reporting?
    6. Report writing?
    7. Other (specify)?

  2. If you use R:
    1. Bear?
    2. Rolled your own (if yes: why)?
    3. Other special packages from CRAN (if yes: which)?

  3. If you use R: In which environment?
    1. Academic?
    2. Pharmaceutic industry
    3. CRO
    4. Consultancy

  4. Do you have any experience in regulatory acceptance of using R?
    if Yes:
    1. Accepted without questions?
    2. Accepted with questions?
    3. Querying validation?
    4. Non-acceptance?

  5. If you don't use R: why?
So, friends, since you all have nicknames, except the well-known Admin and me, I guarantee handling of your answers as strictly anonymous ;-).


Edit: Moved to new category Surveys. [Helmut]

Regards,

Detlew
Helmut
★★★
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Homepage
Vienna, Austria,
2010-04-08 18:19
(5103 d 14:35 ago)

@ d_labes
Posting: # 5048
Views: 6,423
 

 R use in BE/BA

[image]Dear D Labes!

1. Yes

a. Primarily (much more comfortable than my commercial programs).
b. Only in connection with 2.c.
c. Sometimes.
d. As a backup and to obtain parts of the analysis which are not covered by commercial software. :angry:
g. Teaching.

2.

a.
b. Modified S-Plus scripts from B Pikounis, TE Bradstreet and SP Millard (see here).
c. PK-package (Jaki and Wolfsegger) for sparse sampling


3. d.

4.

a.
c. No (already stated a.).See this document of the R Foundation as a starter. Here's another article.


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Helmut Schütz
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d_labes
★★★

Berlin, Germany,
2010-04-09 10:58
(5102 d 21:57 ago)

@ Helmut
Posting: # 5062
Views: 6,253
 

 R use in BE/BA sample size

Dear Helmut,

thanx for participating.

❝ 1. Yes a. Primarily (much more comfortable than my commercial programs).

(underlined by me)

Can you explain that in more detail?

Regards,

Detlew
Helmut
★★★
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Homepage
Vienna, Austria,
2010-04-09 21:01
(5102 d 11:54 ago)

@ d_labes
Posting: # 5069
Views: 6,268
 

 GUI

Dear D. Labes,

have you ever used nQuery?

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Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
d_labes
★★★

Berlin, Germany,
2010-04-12 11:48
(5099 d 21:06 ago)

@ Helmut
Posting: # 5083
Views: 6,236
 

 nQuery by-passed

Dear Helmut,

❝ have you ever used nQuery?


No. Seems this is a fortune for me :-D?

I have PASS at hand. Rather comprehensive but you need a deep understanding to figure out what the input parameters are and what method of sample size to choose from. For the field of BE studies it is rather overkill.

Regards,

Detlew
yjlee168
★★★
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Homepage
Kaohsiung, Taiwan,
2010-04-08 23:23
(5103 d 09:31 ago)

@ d_labes
Posting: # 5054
Views: 6,458
 

 R use in BE/BA

Dear d_labes,

❝ Since I'm very interested in using R in planning and


We've all known that and it's not a news. You're definitely a pro useR, as well as Power to know of course.

❝ evaluation of BE/BA studies, but as you know I'm an Old scummy SAS dog :-D

❝ somehow lazy to make the transition, here some questions for my and


I heard of this before... again "Welcome on board!" :-D
  1. Yes --> a, b, c & d
  2. a, b (because of a) & c (also because of coding Bear, and others which may not be BE/BA related packages, such ivivc, stab, pkfit & tdm)
  3. a, b & d
  4. No and Yes. myself? No! but some Bear users may be YES from different countries, such as Australia or Japan... Once I got validation query from one of users for Bear.--> a and c (I guess)
  5. only if one day Power to know merges R... but I guess it will not happen.

❝ So, friends, since you all have nicknames, except the well-known Admin and

❝ me, I guarantee handling of your answers as strictly anonymous


Why do you say that? :ponder: Most Bear users tell us that they're very happy about using Bear. Don't be shy. ;-)

All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
d_labes
★★★

Berlin, Germany,
2010-04-09 10:53
(5102 d 22:02 ago)

@ yjlee168
Posting: # 5061
Views: 6,333
 

 R and SAS blowhards

Dear Yung-jin,

❝ ... You're definitely a pro useR, as well as Power to know of course.


Thank you for the :flower:s. But no need for eulogy.
I in myself eyes are learning on both fields every day until now.
Who tells you he has mastered such complex software like SAS or R is either lying or a great blowhard.

Your answer to questions 1./2. are not so surprising to me :-D.

❝ ... Most Bear users tell us that they're very happy about using Bear.


Congratulation.

Regards,

Detlew
ElMaestro
★★★

Denmark,
2010-04-11 23:36
(5100 d 09:19 ago)

@ d_labes
Posting: # 5079
Views: 6,260
 

 R use in BE/BA

Dear d_labes,

1g: I use it mainly in a non-work-related way. If/when I -for the fun of it- program something in other languages, then R comes in handy to find bugs (trust me, there are plenty!).
2b: Investigating lm objects (and much more) in deeper detail is necessary every now and then.
3: NA.
4: No.

Best regards,
EM.

Pass or fail!
ElMaestro
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