Bhupesh
☆    

India,
2009-07-21 11:05

Posting: # 3973
Views: 6,634
 

 Dexlansoprazole: Release pattern Question [Tips / Tricks]

Dear All :-)

I want to ask about KAPIDEX (dexlansoprazole) delayed release capsules, where innovator (Takeda) has used a dual release pattern. Kapidex DR Capsules contain two types of pellet

Part A – 25% of drug in granules with enteric coat which dissolves in the pH range not less than 5.0 and not more than 6.0 (Eudragit L 30D – 55)
Part B– 75% of drug in granules with a coat made of a mixture of two enteric polymers (Eudragit L and Eudragit S. releasing after pH 6.0)

And its in vivo profile is like this

[image]

My questions are

Q1. How this dual release pattern is helpful in case of Dexlansoprazole? Is it helpful in improving the BA or for increasing patient compliance or both and how?

Q2. Is this formulation possible without dual release pattern? Is there any otherway round?

Q3. Why is a significant dose of the drug (75%) released in the distal portion of small intestine or in large intestine where the pH is between 6-7.5?

Thanks a lot in advance...
Activity
 Thread view
Bioequivalence and Bioavailability Forum |  Admin contact
19,880 posts in 4,214 threads, 1,364 registered users;
online 8 (0 registered, 8 guests [including 5 identified bots]).
Forum time (Europe/Vienna): 02:42 CEST

Competence, like truth, beauty and contact lenses,
is in the eye of the beholder.    Laurence J. Peter

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5