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raghu ★ India, 2009-03-23 18:38 (5506 d 03:20 ago) Posting: # 3391 Views: 5,716 |
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Dear All, Can any one tell me how to calculate the % absorption of an drug after oral administration Thanks in advance Raghavender |
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drcampos ★ Brazil, 2009-03-23 19:25 (5506 d 02:33 ago) @ raghu Posting: # 3392 Views: 4,647 |
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Dear Raghavender, Please look the description of Wagner-Nelson method at the link below: http://forum.bebac.at/forum_entry.php?id=583 Regards, Daniel Rossi de Campos Brazil |
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raghu ★ India, 2009-03-24 15:40 (5505 d 06:17 ago) @ drcampos Posting: # 3399 Views: 4,508 |
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thanks a lot for giving good and useful information |
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SDavis ★★  UK, 2009-03-24 09:45 (5505 d 12:13 ago) @ raghu Posting: # 3396 Views: 4,681 |
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If you are using WinNonlin you also have the option of numerical Deconvolution available in the base product. This has some advantages in that is does not make assumptions about the PK profile (Wagner-Nelson assumes single compartment PK). In WinNonlin this application can be found under the Tools menu; to access Wagner-Nelson in WinNonlin you need to either write your own model code or purchase the additional IVIVC license. You may want to review this discussion thread; http://www.boomer.org/pkin/PK06/PK2006382.html And also other threads within this forum titled deconvolution for more details, e.g. http://forum.bebac.at/mix_entry.php?id=3193 — Simon Senior Scientific Trainer, Certara™ [link=https://www.youtube.com/watch?v=xX-yCO5Rzag[/link] https://www.certarauniversity.com/dashboard https://support.certara.com/forums/ |
Ing. Helmut Schütz