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drcampos ★ Brazil, 2008-10-08 19:04 (5671 d 11:45 ago) Posting: # 2494 Views: 5,387 |
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Dear All, Recently I have read an article describing a IVIVC. In this article was collected samples at 5, 10, 15, 20, 30 and 45 min in dissolution experiment and at 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6 and 8 h in in vivo study. So, I would like to know how I could correlate these data. The article cite a rescaling procedure. How could I do it? Has someone already used this procedure for IVIVC? Thank you in advance. Daniel Rossi de Campos Brazil Edit: Subject line changed. [Helmut] |
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SDavis ★★  UK, 2009-01-15 10:57 (5572 d 18:53 ago) @ drcampos Posting: # 3034 Views: 4,236 |
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Hi Daniel - sorry if this information comes to you late but I only just saw that no one had responded to your question and although I'm not an IVIVC expert... ❝ The article cite a rescaling procedure. How could I do it? Has someone already used this procedure for IVIVC? To correlate deconvolved Fabs with Fdiss there are various correlation models that can be used. 3 are built into WinNonlin's IVIVC Wizard and you may find the third option would be the equation you'd like to implement: Fabs = Fa*Fdiss(tscale*time-tshift)-Foffset the "tscale" allows you to 'stretch' the Dissolution profile, "tshift" is to account for a lag in absorption You may of course modify a built-in model to account for some other factor. Hope this helps a little, you could also try watching one of Pharsight's free webinars on IVIVC that are hosted under events. Simon — Simon Senior Scientific Trainer, Certara™ [link=https://www.youtube.com/watch?v=xX-yCO5Rzag[/link] https://www.certarauniversity.com/dashboard https://support.certara.com/forums/ |
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drcampos ★ Brazil, 2009-01-19 13:01 (5568 d 16:48 ago) @ SDavis Posting: # 3063 Views: 4,100 |
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Dear Simon, Thank you for your explanation. Regards, Daniel Rossi de Campos |
Ing. Helmut Schütz