drcampos
★    

Brazil,
2008-10-08 19:04
(5650 d 00:37 ago)

Posting: # 2494
Views: 5,335
 

 Time scaling [Dissolution / BCS / IVIVC]

Dear All,

Recently I have read an article describing a IVIVC. In this article was collected samples at 5, 10, 15, 20, 30 and 45 min in dissolution experiment and at 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6 and 8 h in in vivo study. So, I would like to know how I could correlate these data. The article cite a rescaling procedure. How could I do it? Has someone already used this procedure for IVIVC?

Thank you in advance.

Daniel Rossi de Campos
Brazil


Edit: Subject line changed. [Helmut]
SDavis
★★  
Homepage
UK,
2009-01-15 10:57
(5551 d 07:45 ago)

@ drcampos
Posting: # 3034
Views: 4,192
 

 Time in IVIVC

Hi Daniel - sorry if this information comes to you late but I only just saw that no one had responded to your question and although I'm not an IVIVC expert...

❝ The article cite a rescaling procedure. How could I do it? Has someone already used this procedure for IVIVC?


To correlate deconvolved Fabs with Fdiss there are various correlation models that can be used. 3 are built into WinNonlin's IVIVC Wizard and you may find the third option would be the equation you'd like to implement:

Fabs = Fa*Fdiss(tscale*time-tshift)-Foffset

the "tscale" allows you to 'stretch' the Dissolution profile,
"tshift" is to account for a lag in absorption

You may of course modify a built-in model to account for some other factor. Hope this helps a little, you could also try watching one of Pharsight's free webinars on IVIVC that are hosted under events.

Simon

Simon
Senior Scientific Trainer, Certara™
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drcampos
★    

Brazil,
2009-01-19 13:01
(5547 d 05:40 ago)

@ SDavis
Posting: # 3063
Views: 4,058
 

 Time in IVIVC

Dear Simon,

Thank you for your explanation.

Regards,

Daniel Rossi de Campos
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