clinicalservices
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India,
2021-01-05 08:19
(13 d 00:40 ago)

Posting: # 22175
Views: 273
 

 Intra Subject Variability [General Sta­tis­tics]

Dear Members,

We are planning to conduct Steady State study having study design as- T1, T2, R, R.
What should be our approach for calculation of Intra subject variability for such study design.
Thank you all in advance.

Regards.
Helmut
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Vienna, Austria,
2021-01-05 10:38
(12 d 22:22 ago)

@ clinicalservices
Posting: # 22176
Views: 235
 

 CVintra in replicate designs (→ 2 IBDs)

Hi clinicalservices,

» We are planning to conduct Steady State study having study design as- T1, T2, R, R.
» What should be our approach for calculation of Intra subject variability for such study design.

What’s the purpose of the study – a pilot study to select either T1 or T2 for a pivotal study?
If yes, see this presentation (slide 22).

Estimate \(\small{CV_\textrm{intra,1}=\sqrt{\exp(MSE_1)-1}}\) and \(\small{CV_\textrm{intra,2}=\sqrt{\exp(MSE_2)-1}}\) from the respective residual mean squares errors \(\small{(MSE_i})\) of the two incomplete block designs containing (1) T1 and R and (2) T2 and R.

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jag009
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NJ,
2021-01-06 00:11
(12 d 08:49 ago)

@ clinicalservices
Posting: # 22179
Views: 194
 

 Intra Subject Variability

Hi,

» We are planning to conduct Steady State study having study design as- T1, T2, R, R.

Why steady state?

J
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