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clinicalservices ☆ India, 2021-01-05 08:19 (13 d 00:40 ago) Posting: # 22175 Views: 273 |
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Dear Members, We are planning to conduct Steady State study having study design as- T1, T2, R, R. What should be our approach for calculation of Intra subject variability for such study design. Thank you all in advance. Regards. |
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Helmut ★★★   Vienna, Austria, 2021-01-05 10:38 (12 d 22:22 ago) @ clinicalservices Posting: # 22176 Views: 235 |
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Hi clinicalservices, » We are planning to conduct Steady State study having study design as- T1, T2, R, R. » What should be our approach for calculation of Intra subject variability for such study design. What’s the purpose of the study – a pilot study to select either T1 or T2 for a pivotal study? If yes, see this presentation (slide 22). Estimate \(\small{CV_\textrm{intra,1}=\sqrt{\exp(MSE_1)-1}}\) and \(\small{CV_\textrm{intra,2}=\sqrt{\exp(MSE_2)-1}}\) from the respective residual mean squares errors \(\small{(MSE_i})\) of the two incomplete block designs containing (1) T1 and R and (2) T2 and R. — Dif-tor heh smusma 🖖 Helmut Schütz ![[image]](https://static.bebac.at/img/CC by.png) The quality of responses received is directly proportional to the quality of the question asked. 🚮 Science Quotes |
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jag009 ★★★ NJ, 2021-01-06 00:11 (12 d 08:49 ago) @ clinicalservices Posting: # 22179 Views: 194 |
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Hi, » We are planning to conduct Steady State study having study design as- T1, T2, R, R. Why steady state? J |
Ing. Helmut Schütz