yjlee168
★★★

Kaohsiung, Taiwan,
2020-10-20 09:53
(181 d 10:03 ago)

Posting: # 22035
Views: 1,385

## bear: it's time to say goodbye [R for BE/BA]

Dear Helmut & other members,

» [...] PS: Do you plan to implement my -code for ABE of last May in a future release of bear?

Right. If you're talking about the package replicateBE, I have some excuses:
1. if there is a future release of bear? Nope. No such a plan recently (plz see below).
2. I did not have the dataset of replicate BE (> two sequences) to test. The dataset can be analyzed from NCA (subj, time, conc, & ...) , not just statistical analysis with final pivotal parameters (Cmax & AUCs) as bundled with replicateBE package. I tried to compose some for the testing purposes, then I gave it up. I asked some users if they could provide such a dataset with no luck. Quite understood.
3. Some limitations need to be lifted first from the current bear, such as # of sequences & periods. I messed up several times.
4. ReplicateBE package has been good enough and well illustrated in the Forum or Github. Users should be able to deploy it very easily.
5. OK, I'm lazy.
It's been a good time for bear in this Forum since 2008 (as far as I can remember). Lots of supports or excellent suggestions come from the members of this Forum. The reasons for bear to say goodbye at this moment are:
1. it has been stepped down from the official R repository (CRAN) since 2015; so it's not an official package any more;
2. two dependent packages: gWidgets & gWidgetRGtk2 have been removed/retried from CRAN this year; although users still can run GUI of bear right now, I don't know how long it can sustain anyway. So I will try to use tcltk & tcltk2 packages to re-write bear (GUI part); This is supposed to take a lot of time. At least I have a good start with tcltk & tcltk2 with ; In summary, bear is supposed to be retired/removed/deprecated if it was among packages of CRAN.
3. OK, I'm lazy (again).

Finally, I like to thank you all for such long-term supports. Goodbye. 再見/再见。Auf Wiedersehen. Au revoir. さようなら. Прощай. 안녕. Adiós. Αντιο σας. अलविदा.

All the best,
-- Yung-jin Lee
bear v2.8.9:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan http://pkpd.kmu.edu.tw/bear
Helmut
★★★

Vienna, Austria,
2020-10-20 11:30
(181 d 08:26 ago)

@ yjlee168
Posting: # 22036
Views: 1,288

Hi Yung-jin,

» » [...] PS: Do you plan to implement my -code for ABE of last May in a future release of bear?
»
» Right. If you're talking about the package replicateBE,…

Nope, I was only talking about the sample size estimation for bear’s ABE.

» I have some excuses:…

Sure. I don’t expect that you will implement ABEL in bear. Theoretically you could add importFrom("replicateBE", method.A, method.B) to the NAMESPACE and call the functions from bear. Lot of work cause bear’s coding for treatment, sequence, and period differs from their conterparts in replicateBE.
Datasets for testing are given in CSV-format in the {R installation}/library/replicateBE/extdata/ folder and on GitHub. In ’s binary format also on GitHub.

» It's been a good time for bear in this Forum since 2008…

Your initial thread contains an amazing number of 67 posts. It still is the record holder in the forum.

Given the work you’ve I done in the last years I don’t think that you are lazy. On the contrary!
Writing packages can be hell and we rarely – if ever – win laurels for it. Only complaints…

If you decide to retire bear or don’t want to develop it further, I can understand that.
Its loyal users will miss it.

Dif-tor heh smusma 🖖
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
yjlee168
★★★

Kaohsiung, Taiwan,
2020-10-20 13:39
(181 d 06:17 ago)

@ Helmut
Posting: # 22038
Views: 1,210

Hi Helmut,

» [...]
» Nope, I was only talking about the sample size estimation for bear’s ABE.

Yes, I have already included your codes since v2.8.8 released last June.

Click the pop-down menu of 'I want to do', then select 'sample size estimation'.

» Your initial thread contains an amazing number of 67 posts. It still is the record holder in the forum.

Thank you so much.

» If you decide to retire bear or don’t want to develop it further, I can understand that.

I wish I can back with tcltk-built bear soon. Dunno when.

All the best,
-- Yung-jin Lee
bear v2.8.9:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan http://pkpd.kmu.edu.tw/bear
Helmut
★★★

Vienna, Austria,
2020-10-20 13:58
(181 d 05:58 ago)

@ yjlee168
Posting: # 22040
Views: 1,214

## THX!

Hi Yung-jin,

» Yes, I have already included your codes since v2.8.8 released last June.

THX! Since the version-number did not change I missed the update.
v2.8.8 and v2.8.9 work like a charm on  v4.0.3.

» » If you decide to retire bear or don’t want to develop it further, I can understand that.
»
» I wish I can back with tcltk-built bear soon. Dunno when.

No worries. At the end of the day it’s a spare time project, right?

Dif-tor heh smusma 🖖
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
krish85
☆

India,
2020-10-20 13:01
(181 d 06:56 ago)

@ yjlee168
Posting: # 22037
Views: 1,230

## bear: it's time to say goodbye

Dear Yung-jin,

You have always been super helpful and kind.

I sincerely thank you for your support and be there with us whenver required.

Kudos !

And No, You are not lazy...
yjlee168
★★★

Kaohsiung, Taiwan,
2020-10-20 13:43
(181 d 06:13 ago)

@ krish85
Posting: # 22039
Views: 1,216

## bear: it's time to say goodbye

Dear Krish85,

Thank you too.

All the best,
-- Yung-jin Lee
bear v2.8.9:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan http://pkpd.kmu.edu.tw/bear
Astea
★★

Russia,
2020-10-21 14:36
(180 d 05:20 ago)

@ yjlee168
Posting: # 22043
Views: 1,081

## bear: it's time to say goodbye

Dear yjlee168!

It is very sad to read! You're a great programmer! Bear helped us out so many times!!!...

» Its loyal users will miss it.

We'll definetely miss it!

Hope you'll find the strength to revive Bear in a new quality!

"Being in minority, even a minority of one, did not make you mad"
yjlee168
★★★

Kaohsiung, Taiwan,
2020-10-21 20:07
(179 d 23:49 ago)

@ Astea
Posting: # 22044
Views: 1,055

## Thanks!

Dear Astea,

Thank you too for your input (error report) to bear.

» Hope you'll find the strength to revive Bear in a new quality!

OK & thank you again. I will definitely do my best.

All the best,
-- Yung-jin Lee
bear v2.8.9:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan http://pkpd.kmu.edu.tw/bear