Helmut
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2020-08-31 15:33
(23 d 12:33 ago)

Posting: # 21903
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 Assumptions in BE [Off Topic]

Dear all,

discovered* a nice formula expressing two main assumptions in BE, namely that doses and clearances are equal.$$\frac{F_\textrm{T}}{F_\textrm{R}}=\frac{\frac{AUC_\textrm{T}\times CL_\textrm{T}}{dose_\textrm{T}}}{\frac{AUC_\textrm{R}\times CL_\textrm{R}}{dose_\textrm{R}}}=\frac{AUC_\textrm{T}\times CL_\textrm{T}}{AUC_\textrm{R}\times CL_\textrm{R}}=\frac{AUC_\textrm{T}}{AUC_\textrm{R}}$$

  • Loisios-Konstantinidis I, Hens B, Mitra A, Kim A, Chiann C, Cristofoletti R. Using Physiologically Based Pharmacokinetic Modeling to Assess the Risks of Failing Bioequivalence Criteria: a Tale of Two Ibuprofen Products. AAPS J 2020;22:113. doi:10.1208/s12248-020-00495-4.

Dif-tor heh smusma 🖖
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